Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of …
S McGaraughty, KL Chu, CT Wismer, J Mikusa… - … of Pharmacology and …, 2001 - ASPET
The present study investigated 1) antihyperalgesic actions of a novel and selective
adenosine kinase (AK) inhibitor, A-134974 (IC50= 60 pM), in the carrageenan model of …
adenosine kinase (AK) inhibitor, A-134974 (IC50= 60 pM), in the carrageenan model of …
A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats
CZ Zhu, J Mikusa, KL Chu, M Cowart, EA Kowaluk… - Brain research, 2001 - Elsevier
Extracellular levels of adenosine (ADO) can be raised through inhibition of adenosine
kinase (AK), a primary metabolic enzyme for ADO. AK inhibitors have shown antinociceptive …
kinase (AK), a primary metabolic enzyme for ADO. AK inhibitors have shown antinociceptive …
Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor
MF Jarvis, H Yu, S McGaraughty, CT Wismer, J Mikusa… - Pain, 2002 - Elsevier
Adenosine (ADO) is an inhibitory neuromodulator that can increase nociceptive thresholds
in response to noxious stimulation. Inhibition of the ADO-metabolizing enzyme, adenosine …
in response to noxious stimulation. Inhibition of the ADO-metabolizing enzyme, adenosine …
Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats
MF Jarvis, J Mikusa, KL Chu, CT Wismer… - Pharmacology …, 2002 - Elsevier
Inhibitors of adenosine kinase (AK) enhance extracellular concentrations of the inhibitory
neuromodulator adenosine (ADO) at sites of tissue hyperexcitability and produce …
neuromodulator adenosine (ADO) at sites of tissue hyperexcitability and produce …
The effect of ABT‐702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury
R Suzuki, LC Stanfa, EA Kowaluk… - British journal of …, 2001 - Wiley Online Library
Adenosine (ADO) receptor activation modulates sensory transmission in the dorsal horn.
Little is known about the circumstances underlying release of the purine. The present study …
Little is known about the circumstances underlying release of the purine. The present study …
Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action
L Mazzardo-Martins, DF Martins, J Stramosk… - Neuroscience, 2012 - Elsevier
The present study examined the antihyperalgesic effect of a specific inhibitor of Glycogen
Synthase Kinase 3 (GSK3), AR-A014418, on the partial ligation of the sciatic nerve (PSNL) …
Synthase Kinase 3 (GSK3), AR-A014418, on the partial ligation of the sciatic nerve (PSNL) …
Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor
A Poon, J Sawynok - European journal of pharmacology, 1999 - Elsevier
Spinal administration of an adenosine kinase inhibitor, alone or in combination with an
adenosine deaminase inhibitor, produces antinociception in inflammatory pain tests. In the …
adenosine deaminase inhibitor, produces antinociception in inflammatory pain tests. In the …
Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat
A Poon, J Sawynok - Pain, 1998 - Elsevier
The present study examined the spinal antinociceptive effects of adenosine analogs and
inhibitors of adenosine kinase and adenosine deaminase in the carrageenan-induced …
inhibitors of adenosine kinase and adenosine deaminase in the carrageenan-induced …
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl) pyrido [2, 3-d] pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and …
MF Jarvis, H Yu, K Kohlhaas, K Alexander… - … of Pharmacology and …, 2000 - ASPET
Adenosine (ADO) is an inhibitory neuromodulator that can increase nociceptive thresholds
in response to noxious stimulation. Inhibition of the ADO-metabolizing enzyme adenosine …
in response to noxious stimulation. Inhibition of the ADO-metabolizing enzyme adenosine …
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl) pyrido [2, 3-d] pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and …
EA Kowaluk, J Mikusa, CT Wismer, CZ Zhu… - … of Pharmacology and …, 2000 - ASPET
Adenosine kinase (AK; EC 2.7. 1.20) is a key intracellular enzyme regulating intra-and
extracellular concentrations of adenosine (ADO), an endogenous neuromodulator …
extracellular concentrations of adenosine (ADO), an endogenous neuromodulator …