Objective—Vascular smooth muscle cell (VSMC) transformation to an osteochondrogenic
phenotype is an initial step toward arterial calcification, which is highly correlated with …

Objective Vascular calcification is a common pathobiological process which occurs among
the elder population and in patients with diabetes and chronic kidney disease …

Vascular calcification is a major feature of advanced atherosclerosis and highly associated
with cardiovascular diseases. Oxidized low density lipoprotein (Ox-LDL) has been …

Objective: Vascular calcification is highly correlated with cardiovascular disease morbidity
and mortality. Osteoprotegerin (OPG) is a secreted decoy receptor for receptor activator of …

Vascular calcification commonly associated with several pathologies and it has been
suggested to be similar to bone mineralization. The axis RANKL-OPG (receptor activator of …

Background: Vascular calcification is closely related to the all-cause mortality of
cardiovascular events. Basement membrane protein nidogen-2 is a key component of the …

Rationale: Wnt signaling regulates key aspects of diabetic vascular disease. Objective: We
generated SM22-Cre; LRP6 (fl/fl); LDLR−/− mice to determine contributions of Wnt …

Vascular calcification often occurs with advancing age, atherosclerosis, various metabolic
disorders such as diabetes mellitus and end-stage renal disease, or in rare genetic …

Objective—Clinical and experimental studies demonstrate the important roles of vascular
smooth muscle cells (VSMC) in the pathogenesis of atherosclerosis. We have previously …

The osteoprotegerin (OPG) and receptor activator of nuclear factor-κB ligand (RANKL)
cytokine system, not only controls bone homeostasis, but has been implicated in regulating …