Background: The interleukin-1-receptor antagonist IL1RA (encoded by the IL1RN gene) is a
potent competitive antagonist to interleukin-1 (IL1) and thereby is mainly involved in the …

Previous data indicate a role of IL-1 and IL-1RA imbalance in bladder carcinoma (BC); the
inhibition of IL-1 signaling might be considered a treatment option. Objective: To assess …

We used gene expression profiling to identify inflammatory cytokines that correlate with
bladder cancer development. Gene expression profiles of the tissue samples were …

Background Bladder cancer cells orchestrate tumour progression by pro-inflammatory
cytokines. Cytokines modulate the local tumour microenvironment and increase the …

Inflammatory cytokines may be a critical component of epithelial cancer progression. We
examined the role of interleukin (IL)-5 in the migration of bladder cancer cells. The …

Abstract Purpose: Interleukin (IL)-8 is an important mediator of angiogenesis, tumorigenicity,
and metastasis in transitional cell carcinoma (TCC) of the bladder. Nuclear factor κB (NF …

ABSTRACT A major problem which is poorly understood in the management of bladder
cancer is low sensitivity to chemotherapy and high recurrence after transurethral resection …

Abstract Interleukin 8 (IL-8) is mitogenic and chemotactic for endothelial cells. Within a
neoplasm, IL-8 is secreted by inflammatory and neoplastic cells. The highly tumorigenic and …

The tumor microenvironment impacts tumor progression and individual cells, including
CD4+ T cells, which have been detected in bladder cancer tissues. The detailed mechanism …

Identification of potential tumor markers will help stratify and identify a tumor's malignant
potential and its response to specific therapies. IL-6 has been reported to be a predictor in …