From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases

EH Pilkington, EJA Suys, NL Trevaskis, AK Wheatley… - Acta biomaterialia, 2021 - Elsevier
Vaccination represents the best line of defense against infectious diseases and is crucial in
curtailing pandemic spread of emerging pathogens to which a population has limited …

Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety

I Vlatkovic - Biomedicines, 2021 - mdpi.com
Lipid nanoparticle (LNP) formulated messenger RNA-based (LNP-mRNA) vaccines came
into the spotlight as the first vaccines against SARS-CoV-2 virus to be applied worldwide …

A comprehensive review of mRNA vaccines

V Gote, PK Bolla, N Kommineni, A Butreddy… - International journal of …, 2023 - mdpi.com
mRNA vaccines have been demonstrated as a powerful alternative to traditional
conventional vaccines because of their high potency, safety and efficacy, capacity for rapid …

Principles for designing an optimal mRNA lipid nanoparticle vaccine

E Kon, U Elia, D Peer - Current opinion in biotechnology, 2022 - Elsevier
mRNA Lipid nanoparticles (LNPs) have recently been propelled onto the center stage of
therapeutic platforms due to the success of the SARS-CoV-2 mRNA LNP vaccines (mRNA …

Future considerations for the mRNA-lipid nanoparticle vaccine platform

BZ Igyártó, S Jacobsen, S Ndeupen - Current opinion in virology, 2021 - Elsevier
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) pioneered by Katalin
Karikó and Drew Weissman at the University of Pennsylvania are a promising new vaccine …

Lipid nanoparticles as delivery systems for RNA-based vaccines

BN Aldosari, IM Alfagih, AS Almurshedi - Pharmaceutics, 2021 - mdpi.com
There has been increased interest in the development of RNA-based vaccines for protection
against various infectious diseases and also for cancer immunotherapies. Rapid and cost …

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

N Chaudhary, D Weissman… - Nature reviews Drug …, 2021 - nature.com
Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a
scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the …

The immunostimulatory nature of mRNA lipid nanoparticles

P Sharma, D Hoorn, A Aitha, D Breier, D Peer - Advanced drug delivery …, 2024 - Elsevier
Abstract mRNA-Lipid nanoparticles (LNPs) are at the forefront of global medical research.
With the development of mRNA-LNP vaccines to combat the COVID-19 pandemic, the …

Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine

H Muramatsu, K Lam, C Bajusz, D Laczkó, K Karikó… - Molecular Therapy, 2022 - cell.com
Lipid nanoparticle (LNP)-formulated nucleoside-modified mRNA vaccines have proven to be
very successful in the fight against the coronavirus disease 2019 (COVID-19) pandemic …

Lipid nanoparticles as promising carriers for mRNA vaccines for viral lung infections

M Hajiaghapour Asr, F Dayani, F Saedi Segherloo… - Pharmaceutics, 2023 - mdpi.com
In recent years, there has been an increase in deaths due to infectious diseases, most
notably in the context of viral respiratory pathogens. Consequently, the focus has shifted in …