The lysosome is the final destination for degradation of endocytic cargo, plasma membrane
constituents, and intracellular components sequestered by macroautophagy. Fusion of …

Endocytic, autophagic, and phagocytic vesicles move on microtubule tracks to fuse with
lysosomes. Small GTPases, such as Rab7 and Arl8b, recruit their downstream effectors to …

Multiple sources contribute membrane and protein machineries to construct functional
macroautophagic/autophagic structures. However, the underlying molecular mechanisms …

It has been indicated that the Golgi apparatus contributes to autophagy, but how it is
involved in autophagosome formation and maturation is not well understood. Here we show …

The small GTP ase Rab7 is a key organizer of receptor sorting and lysosomal degradation
by recruiting of a variety of effectors depending on its GDP/GTP‐bound state. However …

Autophagy is the main homeostatic pathway guiding cytosolic materials for degradation by
the lysosome. Maturation of autophagosomes requires their transport towards the …

The homotypic fusion and protein sorting (HOPS) complex is a multi‐subunit complex
conserved from yeast to mammals that regulates late endosome and lysosome fusion …

Rab7 promotes fusion of autophagosomes and late endosomes with lysosomes in yeast and
metazoan cells, acting together with its effector, the tethering complex HOPS. Here we show …

The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering
complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the …

Autophagy is the main eukaryotic degradation pathway for long-lived proteins, protein
aggregates, and cytosolic organelles. Although the protein machinery involved in the …