[HTML][HTML] PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins
DG McEwan, D Popovic, A Gubas, S Terawaki… - Molecular cell, 2015 - cell.com
The lysosome is the final destination for degradation of endocytic cargo, plasma membrane
constituents, and intracellular components sequestered by macroautophagy. Fusion of …
constituents, and intracellular components sequestered by macroautophagy. Fusion of …
The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes
Endocytic, autophagic, and phagocytic vesicles move on microtubule tracks to fuse with
lysosomes. Small GTPases, such as Rab7 and Arl8b, recruit their downstream effectors to …
lysosomes. Small GTPases, such as Rab7 and Arl8b, recruit their downstream effectors to …
RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells
X Ding, X Jiang, R Tian, P Zhao, L Li, X Wang, S Chen… - Autophagy, 2019 - Taylor & Francis
Multiple sources contribute membrane and protein machineries to construct functional
macroautophagic/autophagic structures. However, the underlying molecular mechanisms …
macroautophagic/autophagic structures. However, the underlying molecular mechanisms …
GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion
It has been indicated that the Golgi apparatus contributes to autophagy, but how it is
involved in autophagosome formation and maturation is not well understood. Here we show …
involved in autophagosome formation and maturation is not well understood. Here we show …
Phosphatidylinositol 4, 5‐bisphosphate controls Rab7 and PLEKHM 1 membrane cycling during autophagosome–lysosome fusion
T Baba, DJ Toth, N Sengupta, YJ Kim, T Balla - The EMBO journal, 2019 - embopress.org
The small GTP ase Rab7 is a key organizer of receptor sorting and lysosomal degradation
by recruiting of a variety of effectors depending on its GDP/GTP‐bound state. However …
by recruiting of a variety of effectors depending on its GDP/GTP‐bound state. However …
[HTML][HTML] Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway
RH Wijdeven, H Janssen, L Nahidiazar… - Nature …, 2016 - nature.com
Autophagy is the main homeostatic pathway guiding cytosolic materials for degradation by
the lysosome. Maturation of autophagosomes requires their transport towards the …
the lysosome. Maturation of autophagosomes requires their transport towards the …
The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes
The homotypic fusion and protein sorting (HOPS) complex is a multi‐subunit complex
conserved from yeast to mammals that regulates late endosome and lysosome fusion …
conserved from yeast to mammals that regulates late endosome and lysosome fusion …
Rab2 promotes autophagic and endocytic lysosomal degradation
Rab7 promotes fusion of autophagosomes and late endosomes with lysosomes in yeast and
metazoan cells, acting together with its effector, the tethering complex HOPS. Here we show …
metazoan cells, acting together with its effector, the tethering complex HOPS. Here we show …
[HTML][HTML] C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy
S Zhang, M Tong, D Zheng, H Huang, L Li… - Nature …, 2023 - nature.com
The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering
complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the …
complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the …
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport
S Pankiv, EA Alemu, A Brech, JA Bruun… - Journal of Cell …, 2010 - rupress.org
Autophagy is the main eukaryotic degradation pathway for long-lived proteins, protein
aggregates, and cytosolic organelles. Although the protein machinery involved in the …
aggregates, and cytosolic organelles. Although the protein machinery involved in the …