YB-1: oncoprotein, prognostic marker and therapeutic target?

A Lasham, CG Print, AG Woolley, SE Dunn… - Biochemical …, 2013 - portlandpress.com
Hanahan and Weinberg have proposed the 'hallmarks of cancer'to cover the biological
changes required for the development and persistence of tumours [Hanahan and Weinberg …

Y-box binding protein 1–a prognostic marker and target in tumour therapy

C Kosnopfel, T Sinnberg, B Schittek - European journal of cell biology, 2014 - Elsevier
Y-box binding protein 1 (YB-1) is a multifunctional protein involved in various cellular
processes including both transcriptional and translational regulation of target gene …

[HTML][HTML] YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy

Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …

[HTML][HTML] YB-1 is a transcription/translation factor that orchestrates the oncogenome by hardwiring signal transduction to gene expression

J Wu, AL Stratford, A Astanehe… - Translational …, 2007 - ncbi.nlm.nih.gov
Abstract The Y-box Binding Protein-1 (YB-1) is a highly conserved oncogenic transcription/
translation factor that is expressed in cancers affecting adults and children. It is now believed …

[HTML][HTML] Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

PK Maurya, A Mishra, BS Yadav, S Singh… - Journal of …, 2017 - ncbi.nlm.nih.gov
The Y-box binding protein (YB-1) is known to be a multifunctional transcription and
translation factor during expression of several proteins. It is a vital oncoprotein that regulates …

[HTML][HTML] Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma

Y Fujiwara-Okada, Y Matsumoto, J Fukushi… - British journal of …, 2013 - nature.com
Background: Prognosis of osteosarcoma (OS) with distant metastasis and local recurrence is
still poor. Y-box binding protein-1 (YB-1) is a multifunctional protein that can act as a …

YB-1, the E2F pathway, and regulation of tumor cell growth

A Lasham, W Samuel, H Cao, R Patel… - Journal of the …, 2012 - academic.oup.com
Background Y-box binding factor 1 (YB-1) has been associated with prognosis in many
tumor types. Reduced YB-1 expression inhibits tumor cell growth, but the mechanism is …

[HTML][HTML] YB-1 as a cell cycle-regulated transcription factor facilitating cyclin A and cyclin B1 gene expression

K Jurchott, S Bergmann, U Stein, W Walther… - Journal of Biological …, 2003 - ASBMB
Expression of the Y-box protein YB-1 is increased in proliferating normal and cancer cells,
but its role in cell proliferation and cell cycle progression is unclear. We have identified a cell …

Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells

Y Basaki, K Taguchi, H Izumi, Y Murakami… - European journal of …, 2010 - Elsevier
Y-box binding protein-1 (YB-1) plays pivotal roles in acquisition of global drug resistance
and cell growth promotion through transcriptional activation of genes for both drug …

A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance

A Alkrekshi, W Wang, PS Rana, V Markovic… - Cellular signalling, 2021 - Elsevier
The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain
protein family with multifunctional properties both in the cytoplasm and inside the nucleus …