The glutaminolysis and serine–glycine–one-carbon pathways represent metabolic reactions
that are reprogramed and upregulated in cancer; these pathways are involved in supporting …

Tumor cells have an increased demand for amino acids because of their rapid proliferation
rate. In addition to their need in protein synthesis, several amino acids have other roles in …

Amino acids are indispensable nutrients for both normal and cancer cells. Cancer cells are
unable to synthesize essential amino acids as well as some non‐essential amino acids …

Tumor cells have an increased demand for glucose and amino acids to support their rapid
growth, and also exhibit alterations in biochemical pathways that metabolize these nutrients …

Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and
bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently …

Many cancer cells depend on glutamine as they use the glutaminolysis pathway to generate
building blocks and energy for anabolic purposes. As a result, glutamine transporters are …

The solute carrier family 7 member 11 (SLC7A11), an amino acid transporter protein is
frequently overexpressed in human malignancies. The expression and activity of SLC7A11 …

Background and Purpose Pancreatic cancer is a solid tumour that is often fatal. Hence, there
is an urgent need to identify new drug targets for this disease. Highly proliferating cancer …

The transporters for glutamine and essential amino acids, ASCT2 (solute carrier family 1
member 5, SLC1A5) and LAT1 (solute carrier family 7 member 5, SLC7A5), respectively, are …

SLC6A14 mediates Na+/Cl−-coupled concentrative uptake of a broad-spectrum of amino
acids. It is expressed at low levels in many tissues but up-regulated in certain cancers …