Targeted Activatable Magnetic Resonance (MR) Contrast Agents Sensitive to Inflammation Induced Oxidative Stress

CA Nwasike - 2020 - search.proquest.com
Inflammatory diseases are the leading cause of death in the world accounting for 3 out of 5
deaths. Despite the abundance of diagnostic tools for detecting inflammatory diseases, most …

Activatable superparamagnetic iron oxide nanoparticles scavenge reactive oxygen species in macrophages and endothelial cells

C Nwasike, E Yoo, E Purr, AL Doiron - RSC advances, 2020 - pubs.rsc.org
Reactive oxygen species (ROS) are key markers of inflammation, with varying levels of
superoxide indicating the degree of inflammation. Inflammatory diseases remain the leading …

Incorporation of Targeting Biomolecule Improves Interpolymer Complex-Superparamagnetic Iron Oxide Nanoparticles Attachment to and Activation of T2 MR Signals …

C Nwasike, E Purr, JS Nagi, GJ Mahler… - International Journal of …, 2023 - Taylor & Francis
Introduction Inflammatory diseases are the leading cause of death in the world, accounting
for 3 out of 5 deaths. Despite the abundance of diagnostic tools for detection, most screening …

Activatable interpolymer complex-superparamagnetic iron oxide nanoparticles as magnetic resonance contrast agents sensitive to oxidative stress

E Yoo, HA Cheng, LE Nardacci, DJ Beaman… - Colloids and Surfaces B …, 2017 - Elsevier
Magnetic resonance contrast agents that can be activated in response to specific triggers
hold potential as molecular biosensors that may be of great utility in non-invasive disease …

Synthesizing an MR Contrast Agent Sensitive to Oxidative Stress

S Paige, I Stender - 2024 - scholarworks.uvm.edu
Our work combines nanotechnology and medicine to better detect inflammation, a key factor
in many diseases. We've developed nanoparticles that only react in the presence of …

Activatable nanoparticles: recent advances in redox-sensitive magnetic resonance contrast agent candidates capable of detecting inflammation

C Nwasike, E Purr, E Yoo, JS Nagi, AL Doiron - Pharmaceuticals, 2021 - mdpi.com
The emergence of activatable magnetic resonance (MR) contrast agents has prompted
significant interest in the detection of functional markers of diseases, resulting in the creation …

Nature‐inspired nanoformulations for contrast‐enhanced in vivo MR imaging of macrophages

AB Sigalov - Contrast media & molecular imaging, 2014 - Wiley Online Library
Magnetic resonance imaging (MRI) of macrophages in atherosclerosis requires the use of
contrast‐enhancing agents. Reconstituted lipoprotein particles that mimic native high …

Spatial organization of superparamagnetic iron oxide nanoparticles in/on nano/microsized carriers modulates the magnetic resonance signal

MK Lee, NE Clay, E Ko, CE Smith, L Chen, N Cho… - Langmuir, 2018 - ACS Publications
Superparamagnetic iron oxide nanoparticles (SPIONs) are often encapsulated into drug-
carrying nano/microsized particles for simultaneous magnetic resonance (MR) imaging and …

Sensitive activatable nanoprobes for real‐time ratiometric magnetic resonance imaging of reactive oxygen species and ameliorating inflammation in vivo

X Li, Y Liu, X Qi, S Xiao, Z Xu, Z Yuan, Q Liu… - Advanced …, 2022 - Wiley Online Library
Imaging‐guided real‐time monitoring of the treatment process of inflammatory diseases is
important for the timely adjustment of treatment planning to lower unnecessary side effects …

Ultrasensitive magnetic resonance imaging of systemic reactive oxygen species in vivo for early diagnosis of sepsis using activatable nanoprobes

H Wang, D Yu, B Li, Z Liu, J Ren, X Qu - Chemical Science, 2019 - pubs.rsc.org
Current diagnostic methods for sepsis lack required speed or precision, often failing to make
timely accurate diagnosis for early medical treatment. The systemic excess generation of …