The formation of canonical base pairs through Watson–Crick hydrogen bonding sits at the
heart of the genetic apparatus. The specificity of the base pairing of adenine with …

The fact that nucleic acid bases recognize each other to form pairs is a canonical part of the
dogma of biology. However, they do not recognize each other well enough in water to …

Conspectus Nucleic acids typically form a double helix structure through Watson–Crick base-
pairing. In contrast, non-Watson–Crick base pairs can form other three-dimensional …

Since life began on Earth, the four types of bases (A, G, C, and T (U)) that form two sets of
base pairs have remained unchanged as the components of nucleic acids that replicate and …

To understand why the RNA− RNA duplexes in general has a higher thermodynamic
stability over the corresponding DNA− DNA duplexes, we have measured the p K a values …

We report the properties of hydrophobic isosteres of pyrimidines and purines in synthetic
DNA duplexes. Phenyl nucleosides 1 and 2 are nonpolar isosteres of the natural thymidine …

Recognition of the nucleic acid bases within the DNA scaffold comprises the basis for
transmission of genetic information, dictating protein and cell assembly, organismal …

We describe physicochemical properties in DNA of altered-size nucleobases that retain
Watson− Crick analogous hydrogen-bonding ability. Size-expanded analogues of adenine …

As part of an effort to expand the genetic alphabet, we examined the synthesis of DNA with
six different unnatural nucleotides bearing methoxy-derivatized nucleobase analogues …

We describe the properties in DNA of a set of five nonpolar nucleoside mimics in which
shape is similar but size is increased gradually. The compounds vary in the size of their …