Translated small open reading frames (smORFs) can have important regulatory roles and
encode microproteins, yet their genome-wide identification has been challenging. We …

Thousands of small Open Reading Frames (smORFs) with the potential to encode small
peptides of fewer than 100 amino acids exist in our genomes. However, the number of …

Functional protein-coding small open reading frames (smORFs) are emerging as an
important class of genes. However, the number of translated smORFs in the human genome …

A fully mature mRNA is usually associated to a reference open reading frame encoding a
single protein. Yet, mature mRNAs contain unconventional alternative open reading frames …

Small open reading frames (smORFs) of 100 codons or fewer are usually—if arbitrarily—
excluded from proteome annotations. Despite this, the genomes of many metazoans …

Small open reading frames (smORFs) encoding polypeptides of less than 100 amino acids
in eukaryotes (50 amino acids in prokaryotes) were historically excluded from genome …

Short open reading frames (sORFs) are a common feature of all genomes, but their coding
potential has mostly been disregarded, partly because of the difficulty in determining …

The translatome can be defined as the sum of the RNA sequences that are translated into
proteins in the cell by the ribosomal machinery. Until recently, it was generally assumed that …

Our previous proteomics analysis of small proteins expressed in human K562 cells provided
the first direct evidence of translation of upstream ORFs in human full-length cDNAs (Oyama …

Ribosome profiling has revealed pervasive but largely uncharacterized translation outside of
canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based …