Sepsis is defined as a dysregulated host response to infection that leads to life-threatening
acute organ dysfunction. It afflicts approximately 50 million people worldwide annually and …

Although sepsis was described more than 2,000 years ago, and clinicians still struggle to
define it, there is no “gold standard,” and multiple competing approaches and terms exist …

Purpose Various studies have analyzed sepsis subtypes, yet the reproducibility of such
results remains unclear. This study aimed to determine the reproducibility of sepsis subtypes …

Purpose The heterogeneity in sepsis is held responsible, in part, for the lack of precision
treatment. Many attempts to identify subtypes of sepsis patients identify those with shared …

While we lack absolute answers to define and characterize sepsis, our understanding has
advanced considerably. The excessive prior focus on 'systemic inflammation'has led to the …

Pathogenic sepsis is not a monolithic condition. Three major types of sepsis exist within this
category: bacterial, viral, and fungal, each with its own mechanism of action. While similar in …

To be able to give a clear name or label to a specific collection of signs and symptoms is
important for physicians and patients alike. Having an exact diagnosis helps to identify …

Objectives: To evaluate the relative validity of criteria for the identification of sepsis in an ICU
database. Design: Retrospective cohort study of adult ICU admissions from 2008 to 2012 …

Over the past 30 years, 2 major factors have led to a perceived need for better definitions. In
particular, the increasing sophistication, at least in high-income countries, of modalities …

Importance Sepsis is a heterogeneous syndrome. Identification of distinct clinical
phenotypes may allow more precise therapy and improve care. Objective To derive sepsis …