Cancer is a major public health issue and represents the second leading cause of death in
women worldwide, as female reproductive-related neoplasms are the main cause of …

The G‐protein‐coupled estrogen receptor‐1 (GPER‐1), also known as GPR30, is a novel
estrogen receptor mediating estrogen receptor signaling in multiple cell types. The progress …

The estrogen receptor (ER) has functionality in selected ovarian cancer subtypes and
represents a potential target for therapy. The majority (> 80%) of high grade serous, low …

The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain
receptor that mediates non-genomic estrogen related signaling. After ligand activation …

Estrogens have been implicated in the pathogenesis of various cancers, with increasing
concern regarding the overall rising incidence of disease and exposure to environmental …

Mechanisms of carcinogenesis by estrogen center on its mitogenic and genotoxic potential
on tumor target cells. These models suggest that estrogen receptor (ER) signaling promotes …

Estrogen is involved in numerous physiological and pathophysiological systems. Its role in
driving estrogen receptor-expressing breast cancers is well established, but it also has …

Estrogen can elicit pleiotropic cellular responses via a diversity of estrogen receptors (ERs)—
mediated genomic and rapid non-genomic mechanisms. Unlike the genomic responses …

Estrogens mediate profound effects throughout the body and regulate physiological and
pathological processes in both women and men. The low prevalence of many diseases in …

GPR30, now named GPER1 (G protein-coupled estrogen receptor1) or GPER here, was first
identified as an orphan 7-transmembrane G protein-coupled receptor by multiple …