This chapter reviews the neurological phenotype of Down syndrome (DS) in early
development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as …

Down syndrome (DS) is a condition where a complete or segmental chromosome 21 trisomy
causes variable intellectual disability, and progressive memory loss and neurodegeneration …

Virtually all adults with Down syndrome (DS) show the neuropathological changes of
Alzheimer disease (AD) by the age of 40 years. This association is partially due to …

Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to
play a critical role in the development of AD neuropathology. The overexpression of the …

Individuals with Down syndrome (DS) commonly possess unique neurocognitive and
neurobehavioral profiles that emerge within specific developmental periods. These profiles …

Adults with Down syndrome (DS) have a high incidence of Alzheimer's disease (AD),
providing a unique opportunity to explore the early, preclinical stages of AD neuropathology …

Down syndrome is the most common form of intellectual disability and results from one of the
most complex genetic perturbations that is compatible with survival, trisomy 21. The study of …

Adults with Down syndrome (DS) develop Alzheimer disease (AD) pathology progressively
with age but clinical signs of dementia are delayed by at least 10 years after the first signs of …

Down syndrome (DS) is characterized by increased mortality rates, both during early and
later stages of life, and age‐specific mortality risk remains higher in adults with DS …

The entire DNA sequence for human chromosome 21 is now complete, and it is predicted to
contain only about 225 genes, which is approximately three-fold fewer than the number …