Although the liver has been the focus of intensive investigation in many different fields of
study, this largest visceral organ of the body has received only scant attention from …

The liver is an immunologically distinct organ that contains its own unique population of cells
of the innate and adaptive cellular immune response. The liver is known as a site of …

The liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering
the body via the gut, the liver appears designed to detect, capture, and clear bacteria …

The immunologic properties of the liver confront one with a combination of unique
phenomena. These include graft survival across major histocompatibility antigen disparities …

The physiological function of the liver–such as removal of pathogens and antigens from the
blood, protein synthesis and metabolism–requires an immune response that is adapted to …

The role of the immune system in liver disease is not only complex but also poorly
understood. Immune disturbances are important causes of liver disease and also play a role …

The liver accommodates a variety of cell populations, some of which are primarily engaged
in immune activities. The intrahepatic immunologic processes result from a complex …

From the immunology standpoint, the liver is a peculiar organ for several reasons that range
from its anatomical location to its cytoarchitecture and its variety of specific functions …

Immune mechanisms play a critical pathogenetic role in the majority of liver diseases, and
are of crucial importance in particular in infectious and autoimmune disease affecting the …

The liver regulates T-cell homeostasis, induces T-cell tolerance, and supports intrahepatic T-
cell responses against hepatotropic pathogens. Many data from clinical and preclinical …