Importance Circadian rhythm disturbances occur in symptomatic Alzheimer disease (AD)
and have been hypothesized to contribute to disease pathogenesis. However, it is unknown …

Background Circadian disturbances are commonly seen in people with Alzheimer's disease
and have been reported in individuals without symptoms of dementia but with Alzheimer's …

Aging leads to changes in circadian rhythms, including decreased amplitude or robustness,
altered synchrony with the environment, and reduced coordination of rhythms within body …

Importance Sleep and circadian problems are very common in Alzheimer disease (AD).
Recent animal studies suggest a bidirectional relationship between sleep and β-amyloid …

Objective Normal sleep–wake regulation is dependent upon an oscillatory circadian rhythm
promoting alertness and sleep at appropriate times of day. Circadian rhythms have been …

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however,
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …

Importance Aging is associated with excessive daytime sleepiness (EDS), which has been
linked to cognitive decline in the elderly. However, whether EDS is associated with the …

Objective Delirium is a complex neurocognitive syndrome suspected to be bidirectionally
linked to dementia. Circadian rhythm disturbances likely contribute to dementia …

Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

Objective: Previous cross‐sectional studies have observed alterations in activity rhythms in
dementia patients but the direction of causation is unclear. We determined whether …