Brain injury and stroke are leading causes of adult disability. Motor deficits are common
problems, and their underlying pathological mechanisms remain poorly understood. The …

In the spinal cord serotonin (5-HT) systems modulate the spinal network via various 5-HT
receptors. Serotonin 2A receptor and serotonin 2C receptor (5-HT2A and 2C receptors) are …

Spasticity is a common complication in patients with spinal cord injury (SCI) and adversely
affects patients' quality of life. Little is known about the distribution of the serotonin 1F …

Hyperexcitability of motoneurons is one of the key mechanism that has been demonstrated
to underlie the pathogenesis of spasticity after spinal injury. Serotonin (5-HT) denervation …

Following spinal cord injury (SCI) a series of anatomical and functional plastic changes
occurinthespinalcord, includingreorganizationofthespinalneuronal…, alteration of properties …

Serotonin (5‐hydroxytryptamine; 5‐HT) plays an important role in control of locomotion,
partly through direct effects on motoneurons. Spinal cord complete transection (SCI) results …

Serotonergic (5-HT) receptors are upregulated following spinal cord transection. Stimulation
by administration of serotonergic receptor agonists has been successful in improving …

Serotonin (5-HT), a monoamine neurotransmitter synthesized in various populations of
brainstem neurons, plays an important role in modulating the activity of spinal networks …

Following spinal cord injury (SCI) neurons caudal to the injury are capable of rhythmic
locomotor-related activity that can form the basis for substantial functional recovery of …

The descending serotonergic pathway, which originates in various populations of brainstem
neurons, plays an important role in generating the rhythmic motor pattern associated with …