An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and
limited treatment options. Here we provide a comprehensive census of the bone marrow …
limited treatment options. Here we provide a comprehensive census of the bone marrow …
Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia
J Vadakekolathu, MD Minden, T Hood… - Science translational …, 2020 - science.org
Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous hematological
malignancy. Although immunotherapy may be an attractive modality to exploit in patients …
malignancy. Although immunotherapy may be an attractive modality to exploit in patients …
Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival
The immunologic microenvironment in various solid tumors is aberrant and correlates with
clinical survival. Here, we present a comprehensive analysis of the immune environment of …
clinical survival. Here, we present a comprehensive analysis of the immune environment of …
[HTML][HTML] Immune biology of acute myeloid leukemia: implications for immunotherapy
S Khaldoyanidi, D Nagorsen, A Stein… - Journal of Clinical …, 2021 - ncbi.nlm.nih.gov
Immune surveillance of incipient tumor cells is important for defense against cancer
development. However, active immune evasion is a cancer hallmark. 1 In acute myeloid …
development. However, active immune evasion is a cancer hallmark. 1 In acute myeloid …
Single-cell map of diverse immune phenotypes in the acute myeloid leukemia microenvironment
R Guo, M Lü, F Cao, G Wu, F Gao, H Pang, Y Li… - Biomarker …, 2021 - Springer
Background Knowledge of immune cell phenotypes, function, and developmental trajectory
in acute myeloid leukemia (AML) microenvironment is essential for understanding …
in acute myeloid leukemia (AML) microenvironment is essential for understanding …
Targeting the immune microenvironment in acute myeloid leukemia: a focus on T cell immunity
AJ Lamble, EF Lind - Frontiers in oncology, 2018 - frontiersin.org
Immunotherapies, such as chimeric antigen receptor T cells, bispecific antibodies, and
immune checkpoint inhibitors, have emerged as promising modalities in multiple …
immune checkpoint inhibitors, have emerged as promising modalities in multiple …
The cytokine network in acute myeloid leukemia
M Luciano, PW Krenn, J Horejs-Hoeck - Frontiers in immunology, 2022 - frontiersin.org
Acute myeloid leukemia (AML) is a highly heterogeneous malignancy of the blood and bone
marrow, characterized by clonal expansion of myeloid stem and progenitor cells and rapid …
marrow, characterized by clonal expansion of myeloid stem and progenitor cells and rapid …
Single-cell RNA-seq reveals AML hierarchies relevant to disease progression and immunity
Acute myeloid leukemia (AML) is a heterogeneous disease that resides within a complex
microenvironment, complicating efforts to understand how different cell types contribute to …
microenvironment, complicating efforts to understand how different cell types contribute to …
Extensive remodeling of the immune microenvironment in B cell acute lymphoblastic leukemia
A subset of B cell acute lymphoblastic leukemia (B-ALL) patients will relapse and succumb
to therapy-resistant disease. The bone marrow microenvironment may support B-ALL …
to therapy-resistant disease. The bone marrow microenvironment may support B-ALL …
Single-cell analysis reveals altered tumor microenvironments of relapse-and remission-associated pediatric acute myeloid leukemia
Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …