Abstract The US Environmental Protection Agency has responsibility for assessing
endocrine activity of more than 10 000 chemicals, a task that cannot reasonably be achieved …

This past summer, United States President Bill Clinton signed into law amendments to the
Safe Drinking Water Act and Food Quality Protection Act that include clauses requiring the …

Because of rampant concern that estrogenic chemicals in the environment may be adversely
affecting the health of humans and wildlife, reliable methods for detecting and characterizing …

Thousands of environmental chemicals are subject to regulatory review for their potential to
be endocrine disruptors (ED). In vitro high-throughput screening (HTS) assays have …

With the growing awareness and concern regarding estrogens in the environment, the
selection of reliable and appropriate methods for their detection and characterization has …

Over the last few years, an increased awareness of endocrine disrupting chemicals (EDCs)
and their potential to affect wildlife and humans has produced a demand for practical …

Estrogens are defined by their ability to induce the proliferation of cells of the female genital
tract. The wide chemical diversity of estrogenic compounds precludes an accurate prediction …

The traditional rodent uterotropic response assay has been incorporated into the US
Environmental Protection Agency's screening and testing program for environmental …

Substances that may act as estrogens show a broad chemical structural diversity. To
thoroughly address the question of possible adverse estrogenic effects, reliable methods are …

Methods for assessing proestrogenic and estrogenic activity of xenobiotics (environmental
pollutants and therapeutic agents) are critically evaluated. The uterotropic assay in vivo and …