Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …

It is now well established that antibodies have numerous potential benefits when developed
as therapeutics. Here, we evaluate the technical challenges of raising antibodies to …

The tremendous therapeutic potential of voltage-gated sodium channels (Navs) has been
the subject of many studies in the past and is of intense interest today. Nav1. 7 channels in …

Voltage-gated potassium channels play a key role in human physiology and pathology.
Reflecting their importance, numerous channelopathies have been characterised that arise …

The voltage-gated potassium channel KV 1.3 is a well-established therapeutic target for a
range of autoimmune diseases, in addition to being the site of action of many venom-derived …

Voltage-gated sodium (Na V) channels control the upstroke of the action potentials in
excitable cells. Multiple studies have shown distinct roles of Na V channel subtypes in …

The prominent role of voltage-gated sodium channel 1.7 (Nav1. 7) in nociception was
revealed by remarkable human clinical and genetic evidence. Development of potent and …

Toxins and venom components that target voltage-gated sodium (Na V) channels have
evolved numerous times due to the importance of this class of ion channels in the normal …

Venoms of snakes, scorpions, spiders, insects, sea anemones, and cone snails are complex
mixtures of mostly peptides and small proteins that have evolved for prey capture and/or …

The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …