Injectable Self‐Expanding/Self‐Propelling Hydrogel Adhesive with Procoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage Management

X Zhao, Y Huang, Z Li, J Chen, J Luo, L Bai… - Advanced …, 2024 - Wiley Online Library
Developing hydrogels that can quickly reach deep bleeding sites, adhere to wounds, and
expand to stop lethal and/or noncompressible bleeding in civil and battlefield environments …

Gelable and Adhesive Powder for Lethal Non‐Compressible Hemorrhage Control

K Zhang, Y Xian, M Li, Z Pan, Z Zhu… - Advanced Functional …, 2023 - Wiley Online Library
Hemostatic powders are widely used in clinical and emergency situations but often exhibit
low wet adhesion, cytotoxicity concerns, and do not work well for lethal non‐compressible …

A multifunctional shape-adaptive and biodegradable hydrogel with hemorrhage control and broad-spectrum antimicrobial activity for wound healing

L Gao, J Chen, W Feng, Q Song, J Huo, L Yu… - Biomaterials …, 2020 - pubs.rsc.org
Hemorrhage is the leading cause of preventable death of injured military and civilian
patients, and subsequent infection risks endanger their lives or impede the healing of their …

Flexible dual-functionalized hyaluronic acid hydrogel adhesives formed in situ for rapid hemostasis

P Fan, Q Dong, J Yang, Y Chen, H Yang, S Gu… - Carbohydrate …, 2023 - Elsevier
Hydrogel adhesives integrating both rapid and strong adhesion to blooding tissues and
biocompatibility are highly desired for fast hemostasis. Herein, a flexible hyaluronic acid …

[HTML][HTML] Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing

CY Zou, XX Lei, JJ Hu, YL Jiang, QJ Li, YT Song… - Bioactive materials, 2022 - Elsevier
Bio-adhesive polysaccharide-based hydrogels have attracted much attention in first-aid
hemostasis and wound healing for excellent biocompatibility, antibacterial property and pro …

An injectable rapid‐adhesion and anti‐swelling adhesive hydrogel for hemostasis and wound sealing

S Bian, L Hao, X Qiu, J Wu, H Chang… - Advanced Functional …, 2022 - Wiley Online Library
Injectable hydrogel adhesives integrating both rapid adhesion to wet tissues and anti‐
swelling in humid environments are highly desired for fast hemostasis and wound sealing in …

An Antibacterial and Antiadhesion In Situ Forming Hydrogel with Sol–Spray System for Noncompressible Hemostasis

X Wang, X Zhang, X Yang, X Guo, Y Liu… - … Applied Materials & …, 2022 - ACS Publications
Noncompressible hemorrhage is a major cause of posttrauma death and occupies the
leading position among potentially preventable trauma-associated deaths. Recently …

[HTML][HTML] Hydrogel-based biomaterials engineered from natural-derived polysaccharides and proteins for hemostasis and wound healing

J Cheng, J Liu, M Li, Z Liu, X Wang, L Zhang… - … in Bioengineering and …, 2021 - frontiersin.org
Rapid and effective hemostasis is of great importance to improve the quality of treatment and
save lives in emergency, surgical practice, civilian, and military settings. Traditional …

A chitosan hydrogel sealant with self-contractile characteristic: From rapid and long-term hemorrhage control to wound closure and repair

W Fang, L Yang, L Hong, Q Hu - Carbohydrate Polymers, 2021 - Elsevier
Emergent and long-term hemorrhage control is requisite and beneficial for reducing global
mortality and postoperative complications (eg, second bleeding and adverse tissue …

Polymeric hydrogel systems as emerging biomaterial platforms to enable hemostasis and wound healing

S Pourshahrestani, E Zeimaran… - Advanced …, 2020 - Wiley Online Library
Broad interest in developing new hemostatic technologies arises from unmet needs in
mitigating uncontrolled hemorrhage in emergency, surgical, and battlefield settings …