Importance Osteosarcoma, the most common malignant bone tumor in children and
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …

Osteosarcoma is the predominant form of bone cancer, affecting mostly adolescents. Recent
progress made in molecular genetic studies of osteosarcoma has changed our view on the …

Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in
children and adolescents relative to other age groups. The etiology of this often aggressive …

Background Osteosarcoma (OS) is a bone malignancy which occurs primarily in
adolescents. Since it occurs during a period of rapid growth, genes important in bone …

Osteosarcoma is the most common primary bone malignancy of adolescents and young
adults. To better understand the genetic etiology of osteosarcoma, we performed a …

Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic
without a known genetic or environmental cause. Heritable genetic predisposition …

The etiologic contribution of germline genetic variation to sporadic osteosarcoma is not well
understood. Osteosarcoma is a sentinel cancer of Li-Fraumeni syndrome (LFS), in which …

Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including
structural variations (SVs) and copy number alterations (CNAs). To define the landscape of …

Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …