Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

The hallmarks of cancer were proposed as a logical framework to guide research efforts that
aim to understand the molecular mechanisms and derive treatments for this highly complex …

In the past decade, the development of a genome-editing technology mediated by CRISPR
has made genetic engineering easier than ever, both in vitro and in vivo. CRISPR systems …

One of the fundamental discoveries in the field of biology is the ability to modulate the
genome and to monitor the functional outputs derived from genomic alterations. In order to …

Cancer is the second leading cause of death globally and remains a major economic and
social burden. Although our understanding of cancer at the molecular level continues to …

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-
associated genes (Cas) system has been rapidly harnessed to perform various genomic …

Cancer is one of the most leading causes of mortalities worldwide. It is caused by the
accumulation of genetic and epigenetic alterations in 2 types of genes: tumor suppressor …

Background Cancer is caused by a combination of genetic and epigenetic abnormalities.
Current cancer therapies are limited due to the complexity of their mechanism, underlining …

Cancer is a complex disease caused by combinations of cellular genetic alterations and
heterogeneous microenvironments. The use of the robust and programmable CRISPR-Cas …

The development of genetic engineering in the 1970s marked a new frontier in genome-
editing technology. Gene-editing technologies have provided a plethora of benefits to the life …