Adenosine is a ubiquitous homeostatic substance released from most cells, including
neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …

Adenosine is released from most cells, including neurons and glial cells. Once in the
extracellular space, adenosine modifies cell functioning by operating G-protein-coupled …

Adenosine is present in the brain under physiological conditions and acts on G protein-
coupled receptors. Adenosine regulates neurotransmitter release and neuronal firing rate …

The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …

Adenosine is a ubiquitous chemical messenger that modulates cellular activity in both the
CNS and peripheral organs. 1-5 Adenosine levels in the brain extracellular space increase …

The ability of the extracellular nucleoside adenosine to regulate metabolism has been
intensively studied since the original description of the cardiovascular effects of adenosine …

The 'omnipresence'of adenosine in all nervous system cells (neurons and glia) together with
the intensive release of adenosine following insults, makes adenosine as a sort of …

Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …

Endogenous adenosine is a widely distributed upstream regulator of a broad spectrum of
neurotransmitters, receptors, and signaling pathways that converge to contribute to the …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …