Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells
JJ Kathiriya, C Wang, M Zhou, A Brumwell… - Nature cell …, 2022 - nature.com
Loss of alveolar type 2 cells (AEC2s) and the ectopic appearance of basal cells in the alveoli
characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we …
characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we …
Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis
B Jaeger, JC Schupp, L Plappert, O Terwolbeck… - Nature …, 2022 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. In this
study, we focus on the properties of airway basal cells (ABC) obtained from patients with IPF …
study, we focus on the properties of airway basal cells (ABC) obtained from patients with IPF …
Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis
Stem cells undergo dynamic changes in response to injury to regenerate lost cells.
However, the identity of transitional states and the mechanisms that drive their trajectories …
However, the identity of transitional states and the mechanisms that drive their trajectories …
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung
Aberrant epithelial reprogramming can induce metaplastic differentiation at sites of tissue
injury that culminates in transformed barriers composed of scar and metaplastic epithelium …
injury that culminates in transformed barriers composed of scar and metaplastic epithelium …
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
JR Rock, CE Barkauskas, MJ Cronce… - Proceedings of the …, 2011 - National Acad Sciences
There are currently few treatment options for pulmonary fibrosis. Innovations may come from
a better understanding of the cellular origin of the characteristic fibrotic lesions. We have …
a better understanding of the cellular origin of the characteristic fibrotic lesions. We have …
Regulation of epithelial transitional states in murine and human pulmonary fibrosis
F Wang, C Ting, KA Riemondy… - The Journal of …, 2023 - Am Soc Clin Investig
Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from impaired
regeneration of the alveolar epithelium after injury. During regeneration, type 2 alveolar …
regeneration of the alveolar epithelium after injury. During regeneration, type 2 alveolar …
Single-cell reconstruction of human basal cell diversity in normal and idiopathic pulmonary fibrosis lungs
Rationale: Declining lung function in patients with interstitial lung disease is accompanied
by epithelial remodeling and progressive scarring of the gas-exchange region. There is a …
by epithelial remodeling and progressive scarring of the gas-exchange region. There is a …
[HTML][HTML] Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk
Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic interstitial lung
disease. Median survival is only 3 years, and treatment options are limited. IPF is thought to …
disease. Median survival is only 3 years, and treatment options are limited. IPF is thought to …
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
KK Kim, MC Kugler, PJ Wolters… - Proceedings of the …, 2006 - National Acad Sciences
Mechanisms leading to fibroblast accumulation during pulmonary fibrogenesis remain
unclear. Although there is in vitro evidence of lung alveolar epithelial-to-mesenchymal …
unclear. Although there is in vitro evidence of lung alveolar epithelial-to-mesenchymal …
Type 2 alveolar cells are stem cells in adult lung
CE Barkauskas, MJ Cronce… - The Journal of …, 2013 - Am Soc Clin Investig
Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1
epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells …
epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells …