Drug repurposing for glioblastoma and current advances in drug delivery—a comprehensive review of the literature
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with an
extremely poor prognosis. There is a dire need to develop effective therapeutics to …
extremely poor prognosis. There is a dire need to develop effective therapeutics to …
An alternative pipeline for glioblastoma therapeutics: a systematic review of drug repurposing in glioblastoma
SB Lyne, B Yamini - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma is a devastating malignancy that has continued to prove
resistant to a variety of therapeutics. No new systemic therapy has been approved for use …
resistant to a variety of therapeutics. No new systemic therapy has been approved for use …
Drug repurposing, a fast-track approach to develop effective treatments for glioblastoma
I Ntafoulis, SLW Koolen, S Leenstra, MLM Lamfers - Cancers, 2022 - mdpi.com
Simple Summary Introducing novel and effective treatments against glioblastoma (GBM)
remains an arduous journey as reflected in the negative outcome of most clinical trials. The …
remains an arduous journey as reflected in the negative outcome of most clinical trials. The …
Developments in blood-brain barrier penetrance and drug repurposing for improved treatment of glioblastoma
Glioblastoma (GBM) is one of the most common, deadly, and difficult-to-treat adult brain
tumors. Surgical removal of the tumor, followed by radiotherapy (RT) and temozolomide …
tumors. Surgical removal of the tumor, followed by radiotherapy (RT) and temozolomide …
Current state and future perspective of drug repurposing in malignant glioma
MD Siegelin, E Schneider, MA Westhoff… - Seminars in cancer …, 2021 - Elsevier
Malignant gliomas are still extremely difficult to treat because complete surgical resection is
biologically not feasible due to the invasive nature of these diseases and the proximity of …
biologically not feasible due to the invasive nature of these diseases and the proximity of …
Repurposing drugs for glioblastoma: from bench to bedside
Glioblastoma multiforme is the most common, aggressive and lethal type of brain tumor. It is
a stage IV cancer disease with a poor prognosis, as the current therapeutic options (surgery …
a stage IV cancer disease with a poor prognosis, as the current therapeutic options (surgery …
Drug repurposing for the treatment of glioblastoma multiforme
C Abbruzzese, S Matteoni, M Signore… - Journal of Experimental …, 2017 - Springer
Abstract Background Glioblastoma Multiforme is the deadliest type of brain tumor and is
characterized by very poor prognosis with a limited overall survival. Current optimal …
characterized by very poor prognosis with a limited overall survival. Current optimal …
In search of a breakthrough therapy for glioblastoma multiforme
A Vasilev, R Sofi, L Tong, AG Teschemacher… - Neuroglia, 2018 - mdpi.com
Glioblastoma multiforme (GBM) is an extremely malignant type of brain cancer which
originates from astrocytes or their precursors. Glioblastoma multiforme cells share some …
originates from astrocytes or their precursors. Glioblastoma multiforme cells share some …
A comprehensive review in improving delivery of small-molecule chemotherapeutic agents overcoming the blood-brain/brain tumor barriers for glioblastoma treatment
Glioblastoma (GBM) is the most common and lethal primary brain tumor which is highly
resistant to conventional radiotherapy and chemotherapy, and cannot be effectively …
resistant to conventional radiotherapy and chemotherapy, and cannot be effectively …
Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain
Glioblastoma multiforme, because of its invasive nature, can be considered a disease of the
entire brain. Despite recent advances in surgery, radiotherapy and chemotherapy, current …
entire brain. Despite recent advances in surgery, radiotherapy and chemotherapy, current …