Gli1/DNA interaction is a druggable target for Hedgehog‐dependent tumors
Hedgehog signaling is essential for tissue development and stemness, and its deregulation
has been observed in many tumors. Aberrant activation of Hedgehog signaling is the result …
has been observed in many tumors. Aberrant activation of Hedgehog signaling is the result …
[HTML][HTML] Hedgehog pathway and GLI1 isoforms in human cancer
RL Carpenter, HW Lo - Discovery medicine, 2012 - ncbi.nlm.nih.gov
The Hedgehog signaling pathway regulates normal cell growth and differentiation. When
deregulated, the Hedgehog pathway leads to tumorigenesis and supports more aggressive …
deregulated, the Hedgehog pathway leads to tumorigenesis and supports more aggressive …
Identification of novel GLI1 target genes and regulatory circuits in human cancer cells
Hedgehog (HH) signaling is involved in many physiological processes, and pathway
deregulation can result in a wide range of malignancies. Glioma‐associated oncogene 1 …
deregulation can result in a wide range of malignancies. Glioma‐associated oncogene 1 …
Non-canonical hedgehog signaling pathway in cancer: activation of GLI transcription factors beyond smoothened
S Pietrobono, S Gagliardi, B Stecca - Frontiers in genetics, 2019 - frontiersin.org
The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …
role in controlling cell specification, cell–cell interaction and tissue patterning during …
GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression
EJ Tolosa, MG Fernandez-Barrena, E Iguchi… - Biochemical …, 2020 - portlandpress.com
The Hedgehog-regulated transcription factors GLI1 and GLI2 play overlapping roles in
development and disease; however, the mechanisms underlying their interplay remain …
development and disease; however, the mechanisms underlying their interplay remain …
GLI transcription factors: mediators of oncogenic Hedgehog signalling
The current concept of tumourigenesis holds that cancer results from the progressive
acquisition of mutations that endow affected cells with selective growth advantages by …
acquisition of mutations that endow affected cells with selective growth advantages by …
Targeting Gli transcription activation by small molecule suppresses tumor growth
G Bosco-Clément, F Zhang, Z Chen, HM Zhou, H Li… - Oncogene, 2014 - nature.com
Targeted inhibition of Hedgehog signaling at the cell membrane has been associated with
anticancer activity in preclinical and early clinical studies. Hedgehog signaling involves …
anticancer activity in preclinical and early clinical studies. Hedgehog signaling involves …
Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy
S Pandolfi, B Stecca - Expert reviews in molecular medicine, 2015 - cambridge.org
The HEDGEHOG-GLI (HH-GLI) signalling is a key pathway critical in embryonic
development, stem cell biology and tissue homeostasis. In recent years, aberrant activation …
development, stem cell biology and tissue homeostasis. In recent years, aberrant activation …
Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal
T Shimokawa, U Tostar, M Lauth… - Journal of Biological …, 2008 - ASBMB
Hedgehog (HH) signaling is one of the key pathways with major significance for
embryogenesis, tumorigenesis, and stem cell maintenance. Glioma-associated oncogene 1 …
embryogenesis, tumorigenesis, and stem cell maintenance. Glioma-associated oncogene 1 …
GLI1: a therapeutic target for cancer
JT Avery, R Zhang, RJ Boohaker - Frontiers in oncology, 2021 - frontiersin.org
GLI1 is a transcriptional effector at the terminal end of the Hedgehog signaling (Hh) pathway
and is tightly regulated during embryonic development and tissue patterning/differentiation …
and is tightly regulated during embryonic development and tissue patterning/differentiation …