The forces that govern clonal selection during the genesis and maintenance of specific T cell
responses are complex, but amenable to decryption by interrogation of constituent …

Adaptive evolution is a key feature of T cell immunity. During acute immune responses, T
cells harboring high-affinity T cell antigen receptors (TCRs) are preferentially expanded, but …

A diverse T cell receptor (TCR) repertoire capable of recognizing a broad range of antigenic
peptides is thought to be central to effective pathogen-specific immunity by counteracting …

Control of persistently infecting viruses requires that antiviral CD8+ T cells sustain their
numbers and effector function. In this study, we monitored epitope-specific CD8+ T cells …

Heterogeneity is a hallmark of the adaptive immune system. This is most evident in the
enormous diversity of B and T cell antigen receptors. There is also heterogeneity within …

Adaptive T-cell immunity relies on the recruitment of antigen-specific clonotypes, each
defined by the expression of a distinct T-cell receptor (TCR), from an array of naïve T-cell …

Tracking how individual naive T cells from a natural TCR repertoire clonally expand,
differentiate, and make lineage choices in response to an infection has not previously been …

Despite the pressing need for an AIDS vaccine, the determinants of protective immunity to
HIV remain concealed within the complexity of adaptive immune responses. We dissected …

Helper T cell responses that focus the TCR repertoire of responding clones provide
experimental access to the mechanisms of clonal selection in vivo. Using TCRβ chain …

Clonal expansion of infected CD4+ T cells is a major mechanism of HIV-1 persistence and a
barrier to achieving a cure. Potential causes are homeostatic proliferation, effects of HIV-1 …