Exploring m6A‐RNA methylation as a potential therapeutic strategy for acute lung injury and acute respiratory distress syndrome

R Faraj, Y Liang, A Feng, J Wu, SM Black… - Pulmonary …, 2023 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) is the most common methylation modification in
mammalian messenger RNA (mRNA) and noncoding RNAs. m6A modification plays a role …

The effect of N6-methyladenosine (m6A) factors on the development of acute respiratory distress syndrome in the mouse model

L Fei, G Sun, J Sun, D Wu - Bioengineered, 2022 - Taylor & Francis
Acute respiratory distress syndrome (ARDS) can cause loss of alveolar-capillary membrane
integrity and life-threatening immune responses. The underlying molecular mechanisms of …

[HTML][HTML] METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner

F Cao, G Chen, Y Xu, X Wang, X Tang, W Zhang… - Cell Death & …, 2024 - nature.com
Acute lung injury (ALI) as well as its more severe form, acute respiratory distress syndrome
(ARDS), frequently leads to an uncontrolled inflammatory response. N6-methyladenosine …

Emerging role of N6-methyladenosine RNA methylation in lung diseases

L Xu, L Zhou, C Yan, L Li - Experimental Biology and …, 2022 - journals.sagepub.com
In recent years, with the increase of air pollution, smoking, aging, and respiratory infection,
the incidence rate and mortality of lung diseases are increasing annually, which has …

[HTML][HTML] N6-methyladenosine (m6A) methylation in ischemia–reperfusion injury

W Yao, X Han, M Ge, C Chen, X Xiao, H Li, Z Hei - Cell death & disease, 2020 - nature.com
Abstract Ischemia–reperfusion (I/R) injury is common during surgery and often results in
organ dysfunction. The mechanisms of I/R injury are complex, diverse, and not well …

[HTML][HTML] Comprehensive analysis of m6A modification in lipopolysaccharide-induced acute lung injury in mice

C Xu, C Song, W Wang, B Liu, G Li, T Fu, B Hao, N Li… - Molecular …, 2024 - Springer
Abstract Background N6-Methyladenosine (m6A) methylation is the most prevalent post-
transcriptional modification in mRNA, and plays significant roles in various diseases …

[HTML][HTML] N6-methyladenosine modification: Regulatory mechanisms and therapeutic potential in sepsis

W Wang, H Wang, T Sun - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection and is characterized by multiple biological and clinical features. N 6 …

Immune Infiltration and N (6)‐Methyladenosine ncRNA Isoform Detection in Acute Lung Injury

C Gu, C Li, W Wang, W Yan, Y Yao, M Shi… - Journal of …, 2022 - Wiley Online Library
Acute lung injury (ALI) is a severe form of sepsis that is associated with a high rate of
morbidity and death in critically ill individuals. The emergence of ALI is the result of several …

N6-methyladenosine reader YTH N6-methyladenosine RNA binding protein 3 or insulin like growth factor 2 mRNA binding protein 2 knockdown protects human …

K Xiao, P Liu, P Yan, Y Liu, L Song, Y Liu, L Xie - Bioengineered, 2022 - Taylor & Francis
Lung ischemia/reperfusion (I/R) injury (LIRI) is a common complication after lung
transplantation, embolism, and trauma. N6-methyladenosine (m6A) methylation modification …

[HTML][HTML] Tamping Down the Fire: Taming Pyroptosis through RNA Methylation in Acute Lung Injury

KWD Shin, RB Hamanaka - American Journal of Respiratory Cell …, 2024 - atsjournals.org
The recent Coronavirus Disease 19 (COVID-19) pandemic has highlighted the need for a
greater understanding of the pathogenesis of Acute Respiratory Distress Syndrome (ARDS) …