Glucose transporters (GLUTs) are responsible for transporting hexose molecules across
cellular membranes. In adipocytes, insulin stimulates glucose uptake by redistributing …

Insulin stimulates glucose uptake in fat and muscle by redistributing GLUT4 glucose
transporters from intracellular membranes to the cell surface. We previously proposed that …

Insulin causes the exocytic translocation of GLUT4 glucose transporters to stimulate glucose
uptake in fat and muscle. Previous results support a model in which TUG traps GLUT4 in …

The trafficking of the insulin-sensitive glucose transporter, GLUT4, is the paradigm of how
cells control the movement of membrane proteins through intricate pathways of transport in …

The transport of glucose across cell membranes is mediated by facilitative glucose
transporters (GLUTs). The recently identified class III GLUT12 is predominantly expressed in …

The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and
plays a vital role in whole body glucose homeostasis. In the absence of insulin, only~ 1% of …

GLUT4 function is dependent on cellular sorting and trafficking mechanisms that result in its
intracellular sequestration in the basal state, and in its rapid redistribution to the plasma …

The human glucose transporters GLUT1 and GLUT3 have a central role in glucose uptake
as canonical members of the Sugar Porter (SP) family. GLUT1 and GLUT3 share a fully …

In basal adipocytes, glucose transporter 4 (GLUT4) is sequestered intracellularly by an
insulin-reversible retention mechanism. Here, we analyze the roles of three GLUT4 …

GLUCOSE TRANSPORT FACILITATORS (GLUT proteins) mediate the transport of glucose
and other monosaccharides into and out of mammalian cells and therefore play a pivotal …