Bladder cancer is one of the common malignant urothelial tumors. Post-translational
modification (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation …

With the rapidly increasing incidence of bladder cancer in China and worldwide, great efforts
have been made to understand the detailed mechanism of bladder cancer tumorigenesis …

Tumors intricately shape a highly immunosuppressive microenvironment, hampering
effective antitumor immune responses through diverse mechanisms. Consequently …

E3 ubiquitin ligases are a large family of proteins that can be classified into three major
structurally distinct types: N-end rule E3s, E3s containing the HECT (Homology to E6AP C …

The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …

Considerable progress has been made in understanding the contribution of E3 ubiquitin
ligases to health and disease, including the pathogenesis of immunological disorders …

The cell membrane system comprises the plasma membrane, endoplasmic reticulum, Golgi
apparatus, lysosome, mitochondria, and nuclear membrane, which are essential for …

Prostate cancer (PCa) is a malignant epithelial tumor of the prostate gland with a high male
cancer incidence. Numerous studies indicate that abnormal function of ubiquitin …

Tumor microenvironments are composed of a myriad of elements, both cellular (immune
cells, cancer-associated fibroblasts, mesenchymal stem cells, etc.) and non-cellular …

With the introduction of multiple new agents, the role of immunotherapy is rapidly expanding
across all malignancies. Bladder cancer is known to be immunogenic and is responsive to …