Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …

It is widely accepted that changes underlying depression and antidepressant‐like effects
involve not only alterations in the levels of neurotransmitters as monoamines and their …

Depression is a devastating and prevalent disease, with profound effects on neural structure
and function; however the etiology and neuropathology of depression remain poorly …

Neuronal plasticity or remodeling is most often discussed with regard to cellular and
behavioral models of learning and memory. However, neuronal plasticity is a fundamental …

Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both
systems likewise contribute to pathophysiology of depression. Recent findings demonstrate …

Chronic stress and depressive-like behaviors in basic neuroscience research have been
associated with impairments of neuroplasticity, such as neuronal atrophy and synaptic loss …

Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with
alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly …

Depression is a common chronic psychiatric disorder that is also often co-morbid with
numerous neurological and immune diseases. Accumulating evidence indicates that …

Major depressive disorder (MDD) is characterized by structural and neurochemical changes
in limbic structures, including the hippocampus, that regulate mood and cognitive functions …

The mechanisms underlying the initiation/onset of, and the recovery from, depression are
still largely unknown; views that neurogenesis in the hippocampus may be important for the …