Human pluripotent stem cell-based in vitro models that reflect human physiology have the
potential to reduce the number of drug failures in clinical trials and offer a cost-effective …

The brain is the most complex organ in the body, controlling our highest functions, as well as
regulating myriad processes which incorporate the entire physiological system. The effects …

There are no effective agents to prevent or treat chemotherapy-induced peripheral
neuropathy (CIPN), the most common non-hematologic toxicity of chemotherapy. Therefore …

Due to the increasing prevalence of neurological disorders and the large number of
untested compounds in the environment, there is a need to develop reliable and efficient …

Abstract Development of effective therapeutics for neurological disorders has historically
been challenging partly because of lack of accurate model systems in which to investigate …

Safety sciences and the identification of chemical hazards have been seen as one of the
most immediate practical applications of human pluripotent stem cell technology. Protocols …

Human in vitro models of brain neurophysiology are needed to investigate molecular and
cellular mechanisms associated with neurological disorders and neurotoxicity. We have …

Current neurotoxicity testing heavily relies on expensive, time consuming and ethically
debated in vivo animal experiments that are unsuitable for screening large numbers of …

The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …

Phenotypic drug discovery requires billions of cells for high-throughput screening (HTS)
campaigns. Because up to several million different small molecules will be tested in a single …