Background Diabetic nephropathy (DN) is a lethal diabetic microvascular complication
characterized by chronic low-grade inflammation. The NOD-like receptor pyrin domain …

Background Nucleotide leukin-rich polypeptide 3 (NLRP3) inflammasome is documented as
a potent target for treating metabolic diseases and inflammatory disorders. Our recent work …

Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney
failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of …

Diabetes mellitus is an increasingly prevalent disease around the globe. The epidemic of
diabetes mellitus and its complications pretenses the foremost health threat globally …

Inflammation reaction mediated by NLRP3 inflammasome and Nrf2-related oxidative stress
are vital participants in the development of diabetic nephropathy (DN) and closely …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Activation of the
nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing …

Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As
the underlying mechanisms of this inflammation remain poorly defined, specific therapies …

Highlights•NLRP3 inflammasome activity plays an important role in inflammatory
responses.•NLRP3 inflammasome is also implicated in diabetic nephropathy (DN) …

Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease worldwide but
current treatments remain suboptimal. The role of inflammation in DN has only recently been …

Abstract Background The Nucleotide binding and oligomerization domain-like
receptorfamily pyrin domain-containing 3 (NLRP3)-inflammasome plays an important role in …