The fundamental underlying paradigm of sexual reproduction is the production of male and
female gametes of sufficient genetic difference and quality that, following syngamy, they …

Spermatogenesis is a complex process of proliferation and differentiation during male germ
cell development involving mitosis, meiosis and spermiogenesis. Endogenous and …

BACKGROUND DNA integrity and stability are critical determinants of cell viability. This is
especially true in the female germline, wherein DNA integrity underpins successful …

Concentration, motility and morphology are parameters commonly used to determine the
fertilization potential of an ejaculate. These parameters give a general view on the quality of …

The genome of all cells is protected at all times by mechanisms collectively known as DNA
repair activity (DRA). Such activity is particularly important at the beginning of human life, ie …

This paper reviews the possible origin of sperm DNA fragmentation and focuses on the
nuclear events associated with spermiogenesis as a potential source of genetic instability …

Female fertility and offspring health are critically dependent on the maintenance of an
adequate supply of high-quality oocytes. Like somatic cells, oocytes are subject to a variety …

DNA damage in the male germline is associated with poor fertilization rates following IVF,
defective preimplantation embryonic development, and high rates of miscarriage and …

DNA damage is one of the most common insults that challenge all cells. To cope, an
elaborate molecular and cellular response has evolved to sense, respond to and correct the …

In mammals, there is a complex and intriguing relationship between DNA repair and
gametogenesis. DNA repair mechanisms are involved not only in the repair of different types …