X-ROS signaling: rapid mechano-chemo transduction in heart
We report that in heart cells, physiologic stretch rapidly activates reduced-form nicotinamide
adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) to produce reactive oxygen …
adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) to produce reactive oxygen …
X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca2+] i
BL Prosser, RJ Khairallah, AP Ziman, CW Ward… - Journal of molecular and …, 2013 - Elsevier
X-ROS signaling is a novel redox signaling pathway that links mechanical stress to changes
in [Ca2+] i. This pathway is activated rapidly and locally within a muscle cell under …
in [Ca2+] i. This pathway is activated rapidly and locally within a muscle cell under …
Mechanical stretch-induced activation of ROS/RNS signaling in striated muscle
Significance: Mechanical activation of reactive oxygen species (ROS) and reactive nitrogen
species (RNS) occurs in striated muscle and affects Ca2+ signaling and contractile function …
species (RNS) occurs in striated muscle and affects Ca2+ signaling and contractile function …
Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes
Stretching of cardiac muscle modulates contraction through the enhancement of the Ca2+
transient, but how this occurs is still not known. We found that stretching of myocytes …
transient, but how this occurs is still not known. We found that stretching of myocytes …
Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle
JP Kerr, P Robison, G Shi, AI Bogush… - Nature …, 2015 - nature.com
In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress
transduced by the microtubule network elicits reactive oxygen species. X-ROS tunes Ca2+ …
transduced by the microtubule network elicits reactive oxygen species. X-ROS tunes Ca2+ …
Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling
Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive
mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an …
mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an …
Coupled Gating Between Individual Skeletal Muscle Ca2+ Release Channels (Ryanodine Receptors)
Excitation-contraction coupling in skeletal muscle requires the release of intracellular
calcium ions (Ca2+) through ryanodine receptor (RyR1) channels in the sarcoplasmic …
calcium ions (Ca2+) through ryanodine receptor (RyR1) channels in the sarcoplasmic …
A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle
BR Nelson, CA Makarewich, DM Anderson… - Science, 2016 - science.org
Muscle contraction depends on release of Ca2+ from the sarcoplasmic reticulum (SR) and
reuptake by the Ca2+ adenosine triphosphatase SERCA. We discovered a putative muscle …
reuptake by the Ca2+ adenosine triphosphatase SERCA. We discovered a putative muscle …
Does nitric oxide modulate cardiac ryanodine receptor function? Implications for excitation–contraction coupling
G Lim, L Venetucci, DA Eisner… - Cardiovascular …, 2008 - academic.oup.com
Nitric oxide (NO) is a highly reactive, free radical signalling molecule that is constitutively
released in cardiomyocytes by both the endothelial and neuronal isoforms of nitric oxide …
released in cardiomyocytes by both the endothelial and neuronal isoforms of nitric oxide …
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle
AM Bellinger, S Reiken, C Carlson, M Mongillo, X Liu… - Nature medicine, 2009 - nature.com
Duchenne muscular dystrophy is characterized by progressive muscle weakness and early
death resulting from dystrophin deficiency. Loss of dystrophin results in disruption of a large …
death resulting from dystrophin deficiency. Loss of dystrophin results in disruption of a large …