We report that in heart cells, physiologic stretch rapidly activates reduced-form nicotinamide
adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) to produce reactive oxygen …

X-ROS signaling is a novel redox signaling pathway that links mechanical stress to changes
in [Ca2+] i. This pathway is activated rapidly and locally within a muscle cell under …

Significance: Mechanical activation of reactive oxygen species (ROS) and reactive nitrogen
species (RNS) occurs in striated muscle and affects Ca2+ signaling and contractile function …

Stretching of cardiac muscle modulates contraction through the enhancement of the Ca2+
transient, but how this occurs is still not known. We found that stretching of myocytes …

In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress
transduced by the microtubule network elicits reactive oxygen species. X-ROS tunes Ca2+ …

Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive
mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an …

Excitation-contraction coupling in skeletal muscle requires the release of intracellular
calcium ions (Ca2+) through ryanodine receptor (RyR1) channels in the sarcoplasmic …

Muscle contraction depends on release of Ca2+ from the sarcoplasmic reticulum (SR) and
reuptake by the Ca2+ adenosine triphosphatase SERCA. We discovered a putative muscle …

Nitric oxide (NO) is a highly reactive, free radical signalling molecule that is constitutively
released in cardiomyocytes by both the endothelial and neuronal isoforms of nitric oxide …

Duchenne muscular dystrophy is characterized by progressive muscle weakness and early
death resulting from dystrophin deficiency. Loss of dystrophin results in disruption of a large …