[HTML][HTML] Dapagliflozin as an autophagic enhancer via LKB1/AMPK/SIRT1 pathway in ovariectomized/d-galactose Alzheimer's rat model
Autophagy and mitochondrial deficits are characteristics of early phase of Alzheimer's
disease (AD). Sodium-glucose cotransporter-2 inhibitors have been nominated as a …
disease (AD). Sodium-glucose cotransporter-2 inhibitors have been nominated as a …
[HTML][HTML] Dapagliflozin/Hesperidin Combination Mitigates Lipopolysaccharide-Induced Alzheimer's Disease in Rats
Alzheimer's disease (AD) is the most common form of neurodegenerative disorders
worldwide. Its pathologic features include massive neuroinflammation with abnormal …
worldwide. Its pathologic features include massive neuroinflammation with abnormal …
[HTML][HTML] Dapagliflozin ameliorates cognitive impairment in Aluminum-chloride-induced Alzheimer's disease via modulation of AMPK/mTOR, oxidative stress and …
Alzheimer's disease (AD) is a progressive neurological illness characterized by memory loss
and cognitive deterioration. Dapagliflozin was suggested to attenuate the memory …
and cognitive deterioration. Dapagliflozin was suggested to attenuate the memory …
Boosting amygdaloid GABAergic and neurotrophic machinery via dapagliflozin-enhanced LKB1/AMPK signaling in anxious demented rats
Anxiety is a neuropsychiatric disturbance that is commonly manifested in various dementia
forms involving Alzheimer's disease (AD). The mechanisms underlying AD-associated …
forms involving Alzheimer's disease (AD). The mechanisms underlying AD-associated …
Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1 …
HH Arab, MY Al-Shorbagy, MA Saad - Chemico-biological interactions, 2021 - Elsevier
Dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has featured
marked anti-inflammatory effects in murine models of myocardial infarction, renal injury, and …
marked anti-inflammatory effects in murine models of myocardial infarction, renal injury, and …
Dapagliflozin improves diabetic cognitive impairment via indirectly modulating the mitochondria homeostasis of hippocampus in diabetic mice
Z Gui, J Wang, Y Zhang, B Wan, Z Ke, Z Ren… - …, 2024 - Wiley Online Library
Cognitive impairment is increasingly recognized as an important comorbidity of diabetes
progression; however, the underlying molecular mechanism is unclear. Dapagliflozin, an …
progression; however, the underlying molecular mechanism is unclear. Dapagliflozin, an …
Dapagliflozin improves behavioral dysfunction of Huntington's disease in rats via inhibiting apoptosis-related glycolysis
AE El-Sahar, AA Rastanawi, MF El-Yamany, MA Saad - Life Sciences, 2020 - Elsevier
Aims Huntington's disease is a rare neurodegenerative disorder which is associated with
defected glucose metabolism with consequent behavioral disturbance including memory …
defected glucose metabolism with consequent behavioral disturbance including memory …
Targeting ROS-dependent AKT/GSK-3β/NF-κB and DJ-1/Nrf2 pathways by dapagliflozin attenuates neuronal injury and motor dysfunction in rotenone-induced …
Dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has emerged
as a promising neuroprotective agent in murine models of epilepsy and obesity-induced …
as a promising neuroprotective agent in murine models of epilepsy and obesity-induced …
[HTML][HTML] Targeting Autophagy, Apoptosis, and Oxidative Perturbations with Dapagliflozin Mitigates Cadmium-Induced Cognitive Dysfunction in Rats
Cognitive decline and Alzheimer-like neuropathology are common manifestations of
cadmium toxicity. Thanks to its antioxidant/anti-apoptotic features, dapagliflozin has …
cadmium toxicity. Thanks to its antioxidant/anti-apoptotic features, dapagliflozin has …
[HTML][HTML] Dapagliflozin alleviates advanced glycation end product induced podocyte injury through AMPK/mTOR mediated autophagy pathway
L Yang, B Liang, J Li, X Zhang, H Chen, J Sun… - Cellular …, 2022 - Elsevier
Excessive accumulation of advanced glycation end products (AGEs) contributes to
autophagy interruption on podocytes and insufficient autophagy on podocytes is …
autophagy interruption on podocytes and insufficient autophagy on podocytes is …