[HTML][HTML] Dapagliflozin as an autophagic enhancer via LKB1/AMPK/SIRT1 pathway in ovariectomized/d-galactose Alzheimer's rat model

WW Ibrahim, AS Kamel, A Wahid… - Inflammopharmacology, 2022 - Springer
Autophagy and mitochondrial deficits are characteristics of early phase of Alzheimer's
disease (AD). Sodium-glucose cotransporter-2 inhibitors have been nominated as a …

[HTML][HTML] Dapagliflozin/Hesperidin Combination Mitigates Lipopolysaccharide-Induced Alzheimer's Disease in Rats

MA Abd Elmaaboud, RS Estfanous, A Atef, AM Kabel… - Pharmaceuticals, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common form of neurodegenerative disorders
worldwide. Its pathologic features include massive neuroinflammation with abnormal …

[HTML][HTML] Dapagliflozin ameliorates cognitive impairment in Aluminum-chloride-induced Alzheimer's disease via modulation of AMPK/mTOR, oxidative stress and …

WA Samman, SM Selim, HM El Fayoumi, NM El-Sayed… - Pharmaceuticals, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurological illness characterized by memory loss
and cognitive deterioration. Dapagliflozin was suggested to attenuate the memory …

Boosting amygdaloid GABAergic and neurotrophic machinery via dapagliflozin-enhanced LKB1/AMPK signaling in anxious demented rats

AS Kamel, A Wahid, NF Abdelkader, WW Ibrahim - Life sciences, 2022 - Elsevier
Anxiety is a neuropsychiatric disturbance that is commonly manifested in various dementia
forms involving Alzheimer's disease (AD). The mechanisms underlying AD-associated …

Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1 …

HH Arab, MY Al-Shorbagy, MA Saad - Chemico-biological interactions, 2021 - Elsevier
Dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has featured
marked anti-inflammatory effects in murine models of myocardial infarction, renal injury, and …

Dapagliflozin improves diabetic cognitive impairment via indirectly modulating the mitochondria homeostasis of hippocampus in diabetic mice

Z Gui, J Wang, Y Zhang, B Wan, Z Ke, Z Ren… - …, 2024 - Wiley Online Library
Cognitive impairment is increasingly recognized as an important comorbidity of diabetes
progression; however, the underlying molecular mechanism is unclear. Dapagliflozin, an …

Dapagliflozin improves behavioral dysfunction of Huntington's disease in rats via inhibiting apoptosis-related glycolysis

AE El-Sahar, AA Rastanawi, MF El-Yamany, MA Saad - Life Sciences, 2020 - Elsevier
Aims Huntington's disease is a rare neurodegenerative disorder which is associated with
defected glucose metabolism with consequent behavioral disturbance including memory …

Targeting ROS-dependent AKT/GSK-3β/NF-κB and DJ-1/Nrf2 pathways by dapagliflozin attenuates neuronal injury and motor dysfunction in rotenone-induced …

HH Arab, MM Safar, NN Shahin - ACS chemical neuroscience, 2021 - ACS Publications
Dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has emerged
as a promising neuroprotective agent in murine models of epilepsy and obesity-induced …

[HTML][HTML] Targeting Autophagy, Apoptosis, and Oxidative Perturbations with Dapagliflozin Mitigates Cadmium-Induced Cognitive Dysfunction in Rats

HH Arab, AH Eid, SE Alsufyani, AM Ashour… - Biomedicines, 2023 - mdpi.com
Cognitive decline and Alzheimer-like neuropathology are common manifestations of
cadmium toxicity. Thanks to its antioxidant/anti-apoptotic features, dapagliflozin has …

[HTML][HTML] Dapagliflozin alleviates advanced glycation end product induced podocyte injury through AMPK/mTOR mediated autophagy pathway

L Yang, B Liang, J Li, X Zhang, H Chen, J Sun… - Cellular …, 2022 - Elsevier
Excessive accumulation of advanced glycation end products (AGEs) contributes to
autophagy interruption on podocytes and insufficient autophagy on podocytes is …