Macrophage polarization, metabolic reprogramming, and inflammatory effects in ischemic heart disease
X Sun, Y Li, Q Deng, Y Hu, J Dong, W Wang… - Frontiers in …, 2022 - frontiersin.org
Macrophages are highly plastic cells, and the polarization-activating actions that represent
their functional focus are closely related to metabolic reprogramming. The metabolic …
their functional focus are closely related to metabolic reprogramming. The metabolic …
Can polarization of macrophage metabolism enhance cardiac regeneration?
C Lantz, A Becker, EB Thorp - Journal of molecular and cellular cardiology, 2021 - Elsevier
While largely appreciated for their antimicrobial and repair functions, macrophages have
emerged as indispensable for the development, homeostasis, and regeneration of tissue …
emerged as indispensable for the development, homeostasis, and regeneration of tissue …
Temporal changes in glucose metabolism reflect polarization in resident and monocyte-derived macrophages after myocardial infarction
AJ Mouton, NM Aitken, SP Moak… - Frontiers in …, 2023 - frontiersin.org
Introduction Metabolic reprogramming from glycolysis to the mitochondrial tricarboxylic acid
(TCA) cycle and oxidative phosphorylation may mediate macrophage polarization from the …
(TCA) cycle and oxidative phosphorylation may mediate macrophage polarization from the …
[HTML][HTML] Immunometabolic cross-talk in the inflamed heart
FM Marelli-Berg, D Aksentijevic - Cell Stress, 2019 - ncbi.nlm.nih.gov
Inflammatory processes underlie many diseases associated with injury of the heart muscle,
including conditions without an obvious inflammatory pathogenic component such as …
including conditions without an obvious inflammatory pathogenic component such as …
Macrophage polarization in hypoxia and ischemia/reperfusion: Insights into the role of energetic metabolism
EI Yakupova, GV Maleev, AV Krivtsov… - Experimental …, 2022 - journals.sagepub.com
Macrophages, the key cells of innate immunity, possess wide phenotypical and functional
heterogeneity. In vitro studies showed that microenvironment signals could induce the so …
heterogeneity. In vitro studies showed that microenvironment signals could induce the so …
[HTML][HTML] Knowledge gaps to understanding cardiac macrophage polarization following myocardial infarction
ML Lindsey, JJ Saucerman… - Biochimica et Biophysica …, 2016 - Elsevier
Following myocardial infarction (MI), macrophages coordinate both pro-inflammatory and
reparative responses of the left ventricle (LV) by reacting to and secreting cytokines …
reparative responses of the left ventricle (LV) by reacting to and secreting cytokines …
Immunometabolism of phagocytes and relationships to cardiac repair
S Zhang, G Bories, C Lantz, R Emmons… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease remains the leading cause of death worldwide. Myocardial ischemia
is a major contributor to cardiovascular morbidity and mortality. In the case of acute …
is a major contributor to cardiovascular morbidity and mortality. In the case of acute …
Dynamic macrophages: understanding mechanisms of activation as guide to therapy for atherosclerotic vascular disease
JL Decano, M Aikawa - Frontiers in Cardiovascular Medicine, 2018 - frontiersin.org
An emerging theory is that macrophages are heterogenous; an attribute that allows them to
change behavior and execute specific functions in disease processes. This review aims to …
change behavior and execute specific functions in disease processes. This review aims to …
Macrophage metabolic signaling during ischemic injury and cardiac repair
EB Thorp - Immunometabolism, 2021 - journals.lww.com
Macrophages are instrumental for the repair of organs that become injured due to ischemia,
yet their potential for healing is sensitive to the availability of metabolites from the …
yet their potential for healing is sensitive to the availability of metabolites from the …
Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction
W Zuo, R Sun, Z Ji, G Ma - Cellular & Molecular Biology Letters, 2023 - Springer
Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …
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