Macrophages are highly plastic cells, and the polarization-activating actions that represent
their functional focus are closely related to metabolic reprogramming. The metabolic …

While largely appreciated for their antimicrobial and repair functions, macrophages have
emerged as indispensable for the development, homeostasis, and regeneration of tissue …

Introduction Metabolic reprogramming from glycolysis to the mitochondrial tricarboxylic acid
(TCA) cycle and oxidative phosphorylation may mediate macrophage polarization from the …

Inflammatory processes underlie many diseases associated with injury of the heart muscle,
including conditions without an obvious inflammatory pathogenic component such as …

Macrophages, the key cells of innate immunity, possess wide phenotypical and functional
heterogeneity. In vitro studies showed that microenvironment signals could induce the so …

Following myocardial infarction (MI), macrophages coordinate both pro-inflammatory and
reparative responses of the left ventricle (LV) by reacting to and secreting cytokines …

Cardiovascular disease remains the leading cause of death worldwide. Myocardial ischemia
is a major contributor to cardiovascular morbidity and mortality. In the case of acute …

An emerging theory is that macrophages are heterogenous; an attribute that allows them to
change behavior and execute specific functions in disease processes. This review aims to …

Macrophages are instrumental for the repair of organs that become injured due to ischemia,
yet their potential for healing is sensitive to the availability of metabolites from the …

Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …