Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis
Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide,
develops almost exclusively in patients with chronic liver disease and advanced fibrosis …
develops almost exclusively in patients with chronic liver disease and advanced fibrosis …
Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma
T Amann, F Bataille, T Spruss, M Mühlbauer… - Cancer …, 2009 - Wiley Online Library
Liver cirrhosis is the main risk factor for the development of hepatocellular carcinoma (HCC).
Activated hepatic stellate cells (HSC) are the effector cells of hepatic fibrosis and also …
Activated hepatic stellate cells (HSC) are the effector cells of hepatic fibrosis and also …
Hepatic stellate cells: central modulators of hepatic carcinogenesis
AI Thompson, KP Conroy, NC Henderson - BMC gastroenterology, 2015 - Springer
Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-
related death worldwide, and is increasing in incidence. Currently, our therapeutic repertoire …
related death worldwide, and is increasing in incidence. Currently, our therapeutic repertoire …
Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
I Mederacke, CC Hsu, JS Troeger, P Huebener… - Nature …, 2013 - nature.com
Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the
lack of detailed knowledge about specific cellular contributors mediating fibrogenesis …
lack of detailed knowledge about specific cellular contributors mediating fibrogenesis …
Hepatic stellate cells and hepatocarcinogenesis
AE Barry, R Baldeosingh, R Lamm, K Patel… - Frontiers in cell and …, 2020 - frontiersin.org
Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma
(HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like …
(HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like …
Initiation of hepatic stellate cell activation extends into chronic liver disease
V De Smet, N Eysackers, V Merens… - Cell Death & …, 2021 - nature.com
Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver
fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently …
fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently …
Hepatocyte–stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma
C Coulouarn, A Corlu, D Glaise, I Guénon… - Cancer research, 2012 - AACR
Many solid malignant tumors arise on a background of inflamed and/or fibrotic tissues,
features that are found in more than 80% hepatocellular carcinomas (HCC). Activated …
features that are found in more than 80% hepatocellular carcinomas (HCC). Activated …
[HTML][HTML] Stellate cells and the development of liver cancer: therapeutic potential of targeting the stroma
C Coulouarn, B Clément - Journal of hepatology, 2014 - Elsevier
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most
common types of primary tumors in the liver. Although major advances have been made in …
common types of primary tumors in the liver. Although major advances have been made in …
Friend or foe? The elusive role of hepatic stellate cells in liver cancer
B Cogliati, CN Yashaswini, S Wang, D Sia… - Nature Reviews …, 2023 - nature.com
Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers
I Mederacke, DH Dapito, S Affò, H Uchinami… - Nature protocols, 2015 - nature.com
Hepatic stellate cells (HSCs) have been identified as the main fibrogenic cell type in the
liver. Hence, efforts to understand hepatic fibrogenesis and to develop treatment strategies …
liver. Hence, efforts to understand hepatic fibrogenesis and to develop treatment strategies …