Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide,
develops almost exclusively in patients with chronic liver disease and advanced fibrosis …

Liver cirrhosis is the main risk factor for the development of hepatocellular carcinoma (HCC).
Activated hepatic stellate cells (HSC) are the effector cells of hepatic fibrosis and also …

Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-
related death worldwide, and is increasing in incidence. Currently, our therapeutic repertoire …

Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the
lack of detailed knowledge about specific cellular contributors mediating fibrogenesis …

Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma
(HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like …

Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver
fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently …

Many solid malignant tumors arise on a background of inflamed and/or fibrotic tissues,
features that are found in more than 80% hepatocellular carcinomas (HCC). Activated …

Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most
common types of primary tumors in the liver. Although major advances have been made in …

Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

Hepatic stellate cells (HSCs) have been identified as the main fibrogenic cell type in the
liver. Hence, efforts to understand hepatic fibrogenesis and to develop treatment strategies …