Mini-review: Perfluorocarbons, oxygen transport, and microcirculation in low flow states: in vivo and in vitro studies

IP Torres Filho - Shock, 2019 - journals.lww.com
The in vivo study of microvascular oxygen transport requires accurate and challenging
measurements of several mass transfer parameters. Although recommended, blood flow …

Perfluorocarbon emulsion improves oxygen transport of normal and sickle cell human blood in vitro

IP Torres Filho, JRP Pedro… - … Research Part A, 2014 - Wiley Online Library
Perfluorocarbons (PFC) are compounds with high gas solubility that could help deliver O2 to
tissues and have been suggested as adjunct therapy to ischemia. Using a newly designed …

[HTML][HTML] Perfluorocarbon-based oxygen carriers: from physics to physiology

J Jägers, A Wrobeln, KB Ferenz - Pflügers Archiv-European Journal of …, 2021 - Springer
Developing biocompatible, synthetic oxygen carriers is a consistently challenging task that
researchers have been pursuing for decades. Perfluorocarbons (PFC) are fascinating …

Perfluorocarbon gas transport: an overview of medical history with yet unrealized potentials

BD Spiess - Shock, 2019 - journals.lww.com
Perfluorocarbon (PFCs) compounds have been a hereto fore under realized pharmaceutical
class of intravenous emulsions and respiratory adjuvants researched extensively since the …

Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics

BD Spiess - Journal of Applied Physiology, 2009 - journals.physiology.org
Perfluorocarbon (PFC) emulsions are halogen-substituted carbon nonpolar oils with
resultant enhanced dissolved respiratory gas (O2, N2, CO2, nitric oxide) capabilities. In the …

Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons

P Cabrales, AG Tsai, JA Frangos… - American Journal …, 2004 - journals.physiology.org
The oxygen transport capacity of fluorocarbons was investigated in the hamster chamber
window model microcirculation to determine the rate at which oxygen is delivered to the …

Perfluorocarbon‐based oxygen carriers: review of products and trials

CI Castro, JC Briceno - Artificial organs, 2010 - Wiley Online Library
A viable blood substitute is still of great necessity throughout the world. Perfluorocarbon‐
based oxygen carriers (PFCOCs) are emulsions that take advantage of the high solubility of …

Perfluorochemicals as oxygen transport vehicles

RP Geycr - Biomaterials, Artificial Cells and Artificial Organs, 1988 - Taylor & Francis
Perfluorochemical liquids (PFC's) are good solvents for gases and as such, have significant
relevance to the field of biology. Approximately 40 ml of oxygen will dissolve in 100 ml of …

Perfluorocarbon-based oxygen delivery

JG Riess - Artificial cells, blood substitutes, and biotechnology, 2006 - Taylor & Francis
The basic properties of perfluorocarbons (PFCs) and PFC emulsions relevant to their use as
oxygen delivery systems are briefly reviewed. The key issues related to the selection of an …

[HTML][HTML] A third generation perfluorocarbon causes thrombocytopenia, platelet dysfunction and changes in blood morphology in a baboon model of systemic …

HF Pidcoke, RE Shade, MC Herzig, BS Schaffer… - Blood, 2013 - Elsevier
A 3rd generation perfluorocarbon (PFC) is under development for the treatment of traumatic
brain injury (TBI). PFCs have high gas solubility and can deliver oxygen to support ischemic …