Obesity is associated with physical inactivity, which exacerbates the health consequences of
weight gain. However, the mechanisms that mediate this association are unknown. We …

Obesity is associated with physical inactivity, which exacerbates the negative health
consequences of obesity. Despite a wide consensus that people with obesity should …

Dopaminergic signaling in the striatum, particularly at dopamine 2 receptors (D2R), has
been a topic of active investigation in obesity research in the past decades. However, it still …

Background The dopamine D 2 receptor (D 2 R) has received much attention in obesity
studies. Data indicate that D 2 R is reduced in obesity and that the TaqA1 D 2 R variant may …

Objective We have previously demonstrated that insulin signaling, through the downstream
signaling kinase Akt, is a potent modulator of dopamine transporter (DAT) activity, which fine …

Background Obesity is a result of a relative excess in energy intake over energy
expenditure. These processes are controlled by genetic, environmental, psychological and …

Physical inactivity is a primary contributor to diseases such as obesity, cardiovascular
disease, and type 2 diabetes. Accelerometry data suggest that a majority of US adults fail to …

Background The prevalence of obesity has increased dramatically worldwide. The obesity
epidemic begs for novel concepts and therapeutic targets that cohesively address “food …

Consistent with the theory that individuals with hypofunctioning reward circuitry overeat to
compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors …

In 2010, Johnson and Kenny provided conclusive evidence that extended access to a
Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors …