[HTML][HTML] Basal ganglia dysfunction contributes to physical inactivity in obesity
DM Friend, K Devarakonda, TJ O'Neal, M Skirzewski… - Cell metabolism, 2017 - cell.com
Obesity is associated with physical inactivity, which exacerbates the health consequences of
weight gain. However, the mechanisms that mediate this association are unknown. We …
weight gain. However, the mechanisms that mediate this association are unknown. We …
[HTML][HTML] Do dopaminergic impairments underlie physical inactivity in people with obesity?
AV Kravitz, TJ O'Neal, DM Friend - Frontiers in human neuroscience, 2016 - frontiersin.org
Obesity is associated with physical inactivity, which exacerbates the negative health
consequences of obesity. Despite a wide consensus that people with obesity should …
consequences of obesity. Despite a wide consensus that people with obesity should …
Striatal dopamine 2 receptor upregulation during development predisposes to diet-induced obesity by reducing energy output in mice
MA Labouesse, AM Sartori… - Proceedings of the …, 2018 - National Acad Sciences
Dopaminergic signaling in the striatum, particularly at dopamine 2 receptors (D2R), has
been a topic of active investigation in obesity research in the past decades. However, it still …
been a topic of active investigation in obesity research in the past decades. However, it still …
Low dopamine D2 receptor increases vulnerability to obesity via reduced physical activity, not increased appetitive motivation
Background The dopamine D 2 receptor (D 2 R) has received much attention in obesity
studies. Data indicate that D 2 R is reduced in obesity and that the TaqA1 D 2 R variant may …
studies. Data indicate that D 2 R is reduced in obesity and that the TaqA1 D 2 R variant may …
[HTML][HTML] Brief exposure to obesogenic diet disrupts brain dopamine networks
Objective We have previously demonstrated that insulin signaling, through the downstream
signaling kinase Akt, is a potent modulator of dopamine transporter (DAT) activity, which fine …
signaling kinase Akt, is a potent modulator of dopamine transporter (DAT) activity, which fine …
[HTML][HTML] Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects
BA de Weijer, E van de Giessen, TA van Amelsvoort… - EJNMMI research, 2011 - Springer
Background Obesity is a result of a relative excess in energy intake over energy
expenditure. These processes are controlled by genetic, environmental, psychological and …
expenditure. These processes are controlled by genetic, environmental, psychological and …
[HTML][HTML] Running from disease: molecular mechanisms associating dopamine and leptin signaling in the brain with physical inactivity, obesity, and type 2 diabetes
GN Ruegsegger, FW Booth - Frontiers in endocrinology, 2017 - frontiersin.org
Physical inactivity is a primary contributor to diseases such as obesity, cardiovascular
disease, and type 2 diabetes. Accelerometry data suggest that a majority of US adults fail to …
disease, and type 2 diabetes. Accelerometry data suggest that a majority of US adults fail to …
[HTML][HTML] Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding
N Speed, C Saunders, AR Davis, WA Owens… - PloS one, 2011 - journals.plos.org
Background The prevalence of obesity has increased dramatically worldwide. The obesity
epidemic begs for novel concepts and therapeutic targets that cohesively address “food …
epidemic begs for novel concepts and therapeutic targets that cohesively address “food …
Weight gain is associated with reduced striatal response to palatable food
Consistent with the theory that individuals with hypofunctioning reward circuitry overeat to
compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors …
compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors …
Dopamine and diet-induced obesity
AG DiFeliceantonio, DM Small - Nature Neuroscience, 2019 - nature.com
In 2010, Johnson and Kenny provided conclusive evidence that extended access to a
Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors …
Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors …