In the last 30 years, it has been convincingly demonstrated that sleep in major depression is
characterized by disturbances of sleep continuity, a reduction of slow wave sleep, a …

Sleep deprivation is a potentially useful non-pharmacological treatment for depression. A
relationship between sleep loss and the onset of mania has been reported, so it is possible …

Some patients with bipolar illness are fortunate enough to have a relatively uncomplicated
course (for example, responding to lithium monotherapy with extended periods of stability); …

In this review, the authors detail our current understanding of the crucial role that sleep and
its disturbances play in bipolar disorder. Multiple lines of evidence suggest that impaired …

Objective: Disturbed sleep is typical for most depressed patients and complaints about
disordered sleep are the hallmarks of the disorder. Polysomnographic sleep research has …

Manipulations of the sleep-wake cycle, whether of duration (total or partial sleep deprivation
[SD]) or timing (partial SD, phase advance), have profound and rapid effects on depressed …

Disturbances of the sleep-wake cycle are frequently seen in affective illness and are
exhibited in other psychiatric illness as well. In addition to being a useful research probe …

Objective: The authors' goal was to test the hypothesis that the antidepressant effect of total
sleep deprivation can be maintained by initially avoiding sleep during a supposedly “critical” …

Background: There are clinical as well as experimental indications that–contrary to what is
generally assumed—late partial sleep deprivation (LPSD) is not as effective as total sleep …

Bipolar disorder is a severe and chronic disorder, ranked in the top 10 leading causes of
disability worldwide. Sleep disturbances are strongly coupled with inter-episode dysfunction …