Fetal growth restriction (FGR) affects 5–10% of pregnancies, leading to clinically significant
fetal morbidity and mortality. FGR placentae frequently exhibit poor vascular branching, but …

Fetal growth restriction (FGR) affects about 5–10% pregnancies and is associated with
poorer outcomes in the perinatal period. Additionally, long standing epidemiological data …

Fetal growth restriction (FGR), which most commonly results from suboptimal placental
function, substantially increases risks for adverse perinatal and long-term outcomes. The …

Introduction Placental functional impairment in pregnancies with fetal growth restriction
(FGR) can arise from fetoplacental vascular abnormalities. We aimed to compare the micro …

Key points A correlation was found between in vivo umbilical artery Doppler velocimetry and
resistance to fetal‐side flow in the human ex vivo dually perfused placenta, highlighting that …

Proper placental vascularization is vital for pregnancy outcomes, but assessing it with
animal models and human explants has limitations. We introduce a 3D in vitro model of …

Aims In early human pregnancy placental trophoblasts migrate along uterine spiral arteries
(SAs) and remodel these vessels into wide-bore conduits in a process essential for …

Intrauterine growth restriction (IUGR) is a pregnancy complication due to placental
dysfunction that prevents the fetus from obtaining enough oxygen and nutrients, leading to …

The placenta is essential for the efficient delivery of nutrients and oxygen from mother to
fetus to maintain normal fetal growth. Dysfunctional placental development underpins many …

The mechanical force of blood flow is a fundamental determinant of vascular homeostasis.
This frictional stimulation of cells, fluid shear stress (FSS), is increasingly recognised as …