Next-generation sequencing and clinical histocompatibility testing

C Cornaby, JL Schmitz, ET Weimer - Human Immunology, 2021 - Elsevier
Histocompatibility testing is essential for donor identification and risk assessment in solid
organ and hematopoietic stem cell transplant. Additionally, it is useful for identifying donor …

Novel alleles in the era of next-generation sequencing-based HLA typing calls for standardization and policy

JN Tran, KR Sherwood, A Mostafa, RV Benedicto… - Frontiers in …, 2023 - frontiersin.org
Next-Generation Sequencing (NGS) has transformed clinical histocompatibility laboratories
through its capacity to provide accurate, high-throughput, high-resolution typing of Human …

Rapid, scalable and highly automated HLA genotyping using next-generation sequencing: a transition from research to diagnostics

M Danzer, N Niklas, S Stabentheiner, K Hofer, J Pröll… - BMC genomics, 2013 - Springer
Background Human leukocyte antigen matching at allelic resolution is proven clinically
significant in hematopoietic stem cell transplantation, lowering the risk of graft-versus-host …

[HTML][HTML] Performance characteristics and validation of next-generation sequencing for human leucocyte antigen typing

ET Weimer, M Montgomery, R Petraroia… - The Journal of Molecular …, 2016 - Elsevier
High-resolution human leukocyte antigen (HLA) matching reduces graft-versus-host disease
and improves overall patient survival after hematopoietic stem cell transplant. Sanger …

Definitions of histocompatibility typing terms

E Nunes, H Heslop, M Fernandez-Vina… - Blood, The Journal …, 2011 - ashpublications.org
Histocompatibility testing for stem cell and solid organ transplantation has become
increasingly complex as newly discovered HLA alleles are described. HLA typing …

[HTML][HTML] Definitions of histocompatibility typing terms: harmonization of histocompatibility typing terms working group

E Nunes, H Heslop, M Fernandez-Vina, C Taves… - Human Immunology, 2011 - Elsevier
Histocompatibility testing for stem cell and solid organ transplantation has become
increasingly complex as newly discovered human leukocyte antigen (HLA) alleles are …

[HTML][HTML] Concurrent typing of over 4000 samples by long-range PCR amplicon-based NGS and rSSO revealed the need to verify NGS typing for HLA allelic dropouts

D Kong, N Lee, IDD Cruz, C Dames, S Maruthamuthu… - Human Immunology, 2021 - Elsevier
Hematopoietic stem cell transplantation (HSCT) from HLA-matched donors significantly
decreases the risks of graft-rejection and graft-versus-host disease. Long-range PCR …

External proficiency testing for histocompatibility and immunogenetics in today and future

FS Oguz - Frontiers in Genetics, 2024 - frontiersin.org
The Histocompatibility and Immunogenetics laboratories provide disease association and
pharmacogenetic analyses as well as the tests required for transplantation immunology and …

16th IHIW : Review of HLA typing by NGS

D De Santis, D Dinauer, J Duke… - International journal …, 2013 - Wiley Online Library
Human leucocyte antigen (HLA) genes play an important role in the success of organ
transplantation and are associated with autoimmune and infectious diseases. Current DNA …

Very low error rates of NGS-based HLA typing at stem cell donor recruitment question the need for a standard confirmatory typing step before donor work-up

DM Baier, JA Hofmann, H Fischer, G Rall… - Bone Marrow …, 2019 - nature.com
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapy for severe
blood diseases. According to the EBMT activity survey, unrelated stem cell donors provided …