Next-generation sequencing and clinical histocompatibility testing
Histocompatibility testing is essential for donor identification and risk assessment in solid
organ and hematopoietic stem cell transplant. Additionally, it is useful for identifying donor …
organ and hematopoietic stem cell transplant. Additionally, it is useful for identifying donor …
Novel alleles in the era of next-generation sequencing-based HLA typing calls for standardization and policy
Next-Generation Sequencing (NGS) has transformed clinical histocompatibility laboratories
through its capacity to provide accurate, high-throughput, high-resolution typing of Human …
through its capacity to provide accurate, high-throughput, high-resolution typing of Human …
Rapid, scalable and highly automated HLA genotyping using next-generation sequencing: a transition from research to diagnostics
Background Human leukocyte antigen matching at allelic resolution is proven clinically
significant in hematopoietic stem cell transplantation, lowering the risk of graft-versus-host …
significant in hematopoietic stem cell transplantation, lowering the risk of graft-versus-host …
[HTML][HTML] Performance characteristics and validation of next-generation sequencing for human leucocyte antigen typing
ET Weimer, M Montgomery, R Petraroia… - The Journal of Molecular …, 2016 - Elsevier
High-resolution human leukocyte antigen (HLA) matching reduces graft-versus-host disease
and improves overall patient survival after hematopoietic stem cell transplant. Sanger …
and improves overall patient survival after hematopoietic stem cell transplant. Sanger …
Definitions of histocompatibility typing terms
E Nunes, H Heslop, M Fernandez-Vina… - Blood, The Journal …, 2011 - ashpublications.org
Histocompatibility testing for stem cell and solid organ transplantation has become
increasingly complex as newly discovered HLA alleles are described. HLA typing …
increasingly complex as newly discovered HLA alleles are described. HLA typing …
[HTML][HTML] Definitions of histocompatibility typing terms: harmonization of histocompatibility typing terms working group
E Nunes, H Heslop, M Fernandez-Vina, C Taves… - Human Immunology, 2011 - Elsevier
Histocompatibility testing for stem cell and solid organ transplantation has become
increasingly complex as newly discovered human leukocyte antigen (HLA) alleles are …
increasingly complex as newly discovered human leukocyte antigen (HLA) alleles are …
[HTML][HTML] Concurrent typing of over 4000 samples by long-range PCR amplicon-based NGS and rSSO revealed the need to verify NGS typing for HLA allelic dropouts
D Kong, N Lee, IDD Cruz, C Dames, S Maruthamuthu… - Human Immunology, 2021 - Elsevier
Hematopoietic stem cell transplantation (HSCT) from HLA-matched donors significantly
decreases the risks of graft-rejection and graft-versus-host disease. Long-range PCR …
decreases the risks of graft-rejection and graft-versus-host disease. Long-range PCR …
External proficiency testing for histocompatibility and immunogenetics in today and future
FS Oguz - Frontiers in Genetics, 2024 - frontiersin.org
The Histocompatibility and Immunogenetics laboratories provide disease association and
pharmacogenetic analyses as well as the tests required for transplantation immunology and …
pharmacogenetic analyses as well as the tests required for transplantation immunology and …
16th IHIW : Review of HLA typing by NGS
D De Santis, D Dinauer, J Duke… - International journal …, 2013 - Wiley Online Library
Human leucocyte antigen (HLA) genes play an important role in the success of organ
transplantation and are associated with autoimmune and infectious diseases. Current DNA …
transplantation and are associated with autoimmune and infectious diseases. Current DNA …
Very low error rates of NGS-based HLA typing at stem cell donor recruitment question the need for a standard confirmatory typing step before donor work-up
DM Baier, JA Hofmann, H Fischer, G Rall… - Bone Marrow …, 2019 - nature.com
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapy for severe
blood diseases. According to the EBMT activity survey, unrelated stem cell donors provided …
blood diseases. According to the EBMT activity survey, unrelated stem cell donors provided …