Mitochondria are critical organelles responsible for the maintenance of cellular energy
homeostasis. Thus, their dysfunction can have severe consequences in cells responsible for …

Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the United
States and APAP-induced hepatotoxicity is initiated by formation of a reactive metabolite …

Acetaminophen (APAP) is a highly effective analgesic, which is safe at therapeutic doses.
However, an overdose can cause hepatotoxicity and even liver failure. APAP toxicity is …

Acetaminophen (APAP) toxicity is the most common cause of acute liver failure and a major
indication for liver transplantion in the United States and Europe. Although significant …

Liver injury and acute liver failure caused by acetaminophen (APAP) overdose is the
clinically most important drug toxicity in Western countries. Mechanistic investigations have …

Background: Acetaminophen (APAP) is a popular analgesic, but overdose causes acute
liver injury and sometimes death. Decades of research have revealed that mitochondrial …

Acetaminophen (APAP) is an analgesic and antipyretic drug used worldwide, which is safe
at therapeutic doses. However, an overdose can induce liver injury and even liver failure …

Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure in the US
and many western countries. It is well known that APAP induces mitochondrial damage to …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the
United States and mechanisms of liver injury induced by APAP overdose have been the …

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …