Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds
Aldose reductase (AR) catalyzes the NADPH-dependent reduction of glucose to sorbitol in
the polyol pathway, which plays an important role in the development of diabetic …
the polyol pathway, which plays an important role in the development of diabetic …
An extensive research on aldose reductase inhibitory effects of new 4H-1, 2, 4-triazole derivatives
Aldose reductase (AR) is a key enzyme, which triggers the excessive accumulation of
sorbitol in insulin independent tissues leading to severe diabetes-induced microvascular …
sorbitol in insulin independent tissues leading to severe diabetes-induced microvascular …
A new series of 2, 4-thiazolidinediones endowed with potent aldose reductase inhibitory activity
In an effort to identify potent aldose reductase (AR) inhibitors, 5-(arylidene) thiazolidine-2, 4-
diones (1–8), which were prepared by the solvent-free reaction of 2, 4-thiazolidinedione with …
diones (1–8), which were prepared by the solvent-free reaction of 2, 4-thiazolidinedione with …
Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors
Aldose reductase (AR) is a crucial enzyme of the polyol pathway through which glucose is
metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic …
metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic …
Identification of a new class of potent aldose reductase inhibitors: design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines
Aldose reductase (AR) acts as a multi-disease target for the design and development of
therapeutic agents for the management of diabetic complications as well as non-diabetic …
therapeutic agents for the management of diabetic complications as well as non-diabetic …
Design, synthesis, and aldose reductase inhibitory effect of some novel carboxylic acid derivatives bearing 2-substituted-6-aryloxo-pyridazinone moiety
The polyol pathway is a two-step metabolic pathway in which glucose is reduced to sorbitol
and then converted to fructose. The first and rate limiting enzyme of this pathway, aldose …
and then converted to fructose. The first and rate limiting enzyme of this pathway, aldose …
1, 2-Benzothiazine 1, 1-dioxide carboxylate derivatives as novel potent inhibitors of aldose reductase
X Chen, S Zhang, Y Yang, S Hussain, M He… - Bioorganic & medicinal …, 2011 - Elsevier
Due to the importance of aldose reductase (ALR2) as a potential drug target in the treatment
of diabetic complications, there are increasing interests in design and synthesis of ALR2 …
of diabetic complications, there are increasing interests in design and synthesis of ALR2 …
Identification of novel pyrazole–rhodanine hybrid scaffolds as potent inhibitors of aldose reductase: design, synthesis, biological evaluation and molecular docking …
In an effort to develop a new class of potent aldose reductase inhibitors, a series of 1, 3-
diarylpyrazole assimilated 3-substituted 4-oxo-2-thioxo-1, 3-thiazolidines (9a–n) was …
diarylpyrazole assimilated 3-substituted 4-oxo-2-thioxo-1, 3-thiazolidines (9a–n) was …
Development of new thiazolidine-2, 4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological …
This research study describes the development of new small molecules based on 2, 4-
thiazolidinedione (2, 4-TZD) and their aldose reductase (AR) inhibitory activities. The …
thiazolidinedione (2, 4-TZD) and their aldose reductase (AR) inhibitory activities. The …
In Vitro Inhibitory Activity and Molecular Docking Study of Selected Natural Phenolic Compounds as AR and SDH Inhibitors**
C Türkeş, Y Demir, Ş Beydemir - ChemistrySelect, 2022 - Wiley Online Library
Polyol pathway enzymes, aldose reductase (EC 1.1. 1.21; AR, ALR2), and sorbitol
dehydrogenase (EC 1.1. 1.14; SDH, SORD) have been widely investigated as the enzymes …
dehydrogenase (EC 1.1. 1.14; SDH, SORD) have been widely investigated as the enzymes …