Association between use of thiopurines or tumor necrosis factor antagonists alone or in combination and risk of lymphoma in patients with inflammatory bowel disease

M Lemaitre, J Kirchgesner, A Rudnichi, F Carrat… - Jama, 2017 - jamanetwork.com
Importance An increased risk of lymphoma has been reported among patients receiving
thiopurines for inflammatory bowel disease (IBD). The risk of lymphoma associated with anti …

Role of thiopurine and anti-TNF therapy in lymphoma in inflammatory bowel disease

LJ Herrinton, L Liu, X Weng, JD Lewis… - Official journal of the …, 2011 - journals.lww.com
OBJECTIVES: The objective of this study was to assess inflammatory bowel disease (IBD)
medications in relation to lymphoma risk. METHODS: Information on IBD and relevant …

Systematic review with meta‐analysis: comparative risk of lymphoma with anti‐tumour necrosis factor agents and/or thiopurines in patients with inflammatory bowel …

A Chupin, V Perduca, A Meyer… - Alimentary …, 2020 - Wiley Online Library
Background The risk of lymphoma in patients with inflammatory bowel disease (IBD) treated
with anti‐TNF agents remains unclear. Aim To assess the comparative risk of lymphoma with …

Risk of malignancies in patients with inflammatory bowel disease treated with thiopurines or anti‐TNF alpha antibodies

F Beigel, A Steinborn, F Schnitzler… - … and drug safety, 2014 - Wiley Online Library
Purpose We aimed to analyse malignancy rates and predictors for the development of
malignancies in a large German inflammatory bowel disease (IBD) cohort treated with …

Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study

L Beaugerie, N Brousse, AM Bouvier, JF Colombel… - The Lancet, 2009 - thelancet.com
Background Reports of an increased risk of lymphoproliferative disorders in patients
receiving thiopurines for inflammatory bowel disease are controversial. We assessed this …

Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6-mercaptopurine: a meta-analysis

DS Kotlyar, JD Lewis, L Beaugerie, A Tierney… - Clinical …, 2015 - Elsevier
Background & Aims Thiopurine therapy for inflammatory bowel disease (IBD) has been
associated with increased risk for lymphoma. We estimated the relative risk of lymphoma in …

Risk of serious and opportunistic infections associated with treatment of inflammatory bowel diseases

J Kirchgesner, M Lemaitre, F Carrat, M Zureik… - Gastroenterology, 2018 - Elsevier
Background & Aims The risk of infection associated with tumor necrosis factor antagonists
(anti-TNF) and thiopurines (combination therapy) is uncertain. We assessed the risk of …

malignancy on thiopurine treatment with special reference to inflammatory bowel disease

MA Smith, PM Irving, AM Marinaki… - Alimentary …, 2010 - Wiley Online Library
Aliment Pharmacol Ther 2010; 32: 119–130 Summary Background Immunosuppression is a
risk factor for carcinogenesis. Thiopurines specifically contribute to this. As thiopurines are …

Risk of lymphoma in patients with ulcerative colitis treated with thiopurines: a nationwide retrospective cohort study

N Khan, AM Abbas, GR Lichtenstein, EV Loftus Jr… - Gastroenterology, 2013 - Elsevier
Background & Aims There is controversy over whether the treatment of patients with
ulcerative colitis (UC) with thiopurines increases their risk of lymphoma. We evaluated the …

Increased risk of acute myeloid leukemias and myelodysplastic syndromes in patients who received thiopurine treatment for inflammatory bowel disease

A Lopez, M Mounier, AM Bouvier, F Carrat… - Clinical …, 2014 - Elsevier
Background & Aims Treatment with immunosuppressive thiopurines such as azathioprine is
associated with an increased risk of leukemogenesis. We assessed the risk of myeloid …