Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection

JAM Tufariello, J Chan, JAL Flynn - The Lancet infectious diseases, 2003 - thelancet.com
Most people infected with Mycobacterium tuberculosis contain the initial infection and
develop latent tuberculosis. This state is characterised by evidence of an immune response …

Latent tuberculosis infection: the final frontier of tuberculosis elimination in the USA

PA LoBue, JH Mermin - The Lancet Infectious Diseases, 2017 - thelancet.com
Since 1989, the USA has been pursuing the goal of tuberculosis elimination. After
substantial progress during the past two decades, the rate of tuberculosis cases in the USA …

Tuberculosis: latency and reactivation

JAL Flynn, J Chan - Infection and immunity, 2001 - Am Soc Microbiol
Tuberculosis is a major cause of death around the world, with most of the 1.5 million deaths
per year attributable to the disease occurring in developing countries. This disease is …

The latent tuberculosis bacillus (IÕll let you know if I ever meet one)[Counterpoint]

I Orme - The International Journal of Tuberculosis and Lung …, 2001 - ingentaconnect.com
IT HAS BEEN ESTIMATED that one third of the people on the planet have been infected with
Mycobacterium tuberculosis. In the majority of cases nothing clinically overt seems to occur …

The ongoing challenge of latent tuberculosis

H Esmail, CE Barry 3rd, DB Young… - … Transactions of the …, 2014 - royalsocietypublishing.org
The global health community has set itself the task of eliminating tuberculosis (TB) as a
public health problem by 2050. Although progress has been made in global TB control, the …

Mechanisms of latency in Mycobacterium tuberculosis

NM Parrish, JD Dick, WR Bishai - Trends in microbiology, 1998 - cell.com
Mycobacterium tuberculosis can persist within the human host for years without causing
disease, in a syndrome known as latent tuberculosis (TB). As one-third of the world …

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

CE Barry 3rd, HI Boshoff, V Dartois, T Dick… - Nature Reviews …, 2009 - nature.com
Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …

Eliminating latent tuberculosis

DB Young, HP Gideon, RJ Wilkinson - Trends in microbiology, 2009 - cell.com
Tuberculosis is recognized as the world's leading bacterial cause of death. Yet 95% of
infection is believed to exist in an asymptomatic 'latent'form that is defined not by the …

Latent tuberculosis infection: myths, models, and molecular mechanisms

NK Dutta, PC Karakousis - Microbiology and Molecular Biology …, 2014 - Am Soc Microbiol
The aim of this review is to present the current state of knowledge on human latent
tuberculosis infection (LTBI) based on clinical studies and observations, as well as …

The long shadow post-tuberculosis

B Allwood, M van der Zalm, G Makanda… - The Lancet Infectious …, 2019 - thelancet.com
is an important piece of work confirming a long-held belief by health workers in the field;
however, death frequently comes only at the end of prolonged periods of suffering and …