Some features of the OPN protein. Indicated sites of O-glycosylation and phosphorylation
are intended to be representative; both vary (phosphorylation in particular) with the source of …

This overview will explore if there is a common thread linking the various putative functions
of osteopontin (OPN). OPN is a negatively charged, glycosylated phosphoprotein with a …

In this review most of the various known, suspected, or postulated functions of osteopontin, a
secreted highly acidic phosphoprotein, are discussed in terms of what we currently know …

Osteopontin (OPN) was first described as a phosphorylated protein secreted by transformed
cells but not by their nontransformed counterparts. Since this initial observation, OPN has …

The cytokine and cell attachment protein osteopontin (OPN) is not necessary for the
development and survival of mice in a clean animal facility. The primary role of OPN appears …

Recent research has led to a better but as yet incomplete understanding of the complex
roles osteopontin plays in mammalian physiology. A soluble protein found in all body fluids …

Osteopontin (OPN) serves both a cell attachment function and a cell signalling function via
the alpha v beta 3 integrin. We have investigated the action on mammalian cells of …

We have generated synthetic peptides corresponding to various portions of human
osteopontin (OPN) and have immunized rabbits and mice with these peptides to generate …

Osteopontin (Opn) is a secreted adhesive, glycosylated phosphoprotein that contains the
arginine‐glycine‐aspartic acid (RGD) cell‐binding sequence that is found in many …

Specific cellular adhesion and migration of cells are important themes in embryonic
development, tumor cell metastasis, wound healing and inflammation. Recent advances in …