Synovial macrophages play an important role in the progression of osteoarthritis (OA). In this
study, we noted that synovial macrophages can activate pyroptosis in a gasdermin d …

The progression of osteoarthritis is associated with chronic synovitis caused by synovial
macrophage infiltration and proinflammatory M1 polarization. Accordingly, repolarization of …

M1 macrophages enrich in rheumatoid arthritis (RA) joints and contribute to persistent
progression of inflammation and destruction. Their apoptosis and polarization toward M2 …

Osteoarthritis (OA) is a common chronic inflammatory disorder. Effective remodeling of
inflammatory microenvironment in the joint is a promising strategy to prevent OA. However …

Osteoarthritis (OA) is the most common joint pathology causing severe pain and disability.
Macrophages play a central role in the pathogenesis of OA. In the joint microenvironment …

Osteoarthritis (OA) is an obstinate, degradative, and complicated disease that has drawn
much attention worldwide. Characterized by its stubborn symptoms and various sequela, OA …

Excessive reactive oxygen species (ROS)-induced mitochondrial damage has impact on
osteoarthritis (OA). Nanozyme mimics as natural enzyme alternatives to scavenge excessive …

Utilization of joint-resident mesenchymal stem cells (MSC) to repair articular cartilage is a
promising strategy in osteoarthritis (OA) therapy but remains a considerable research …

Rheumatoid arthritis (RA) is a chronic, progressive, and systemic inflammatory autoimmune
disease, characterized by synovial inflammation, synovial lining hyperplasia and …

The persistent progression of synovial inflammation and cartilage destruction contributes to
the crosstalk between pro-inflammatory macrophages and activated fibroblast-like …