Molecular pathogenesis of Hodgkin's lymphoma: increasing evidence of the importance of the microenvironment

C Steidl, JM Connors, RD Gascoyne - Journal of Clinical Oncology, 2011 - ascopubs.org
Hodgkin's lymphoma (HL) represents the most common subtype of malignant lymphoma in
young people in the Western world. Most patients can be cured with modern treatment …

Molecular pathogenesis of Hodgkin's lymphoma

D Re, R Kuppers, V Diehl - Journal of Clinical Oncology, 2005 - ascopubs.org
According to the WHO classification, Hodgkin's lymphoma (HL) is subdivided into a classical
variant and a nodular lymphocyte predominant variant which are characterized by the …

The microenvironment in classical Hodgkin lymphoma: an actively shaped and essential tumor component

Y Liu, A Sattarzadeh, A Diepstra, L Visser… - Seminars in cancer …, 2014 - Elsevier
Classical Hodgkin lymphoma (cHL) is characterized by a minority of tumor cells derived from
germinal center B-cells and a vast majority of non-malignant reactive cells. The tumor cells …

New insights in the biology of Hodgkin lymphoma

R Küppers - Hematology 2010, the American Society of …, 2012 - ashpublications.org
Abstract The Hodgkin and Reed/Sternberg (HRS) tumor cells of classical Hodgkin
lymphoma (HL) and the lymphocyte-predominant tumor cells of nodular lymphocyte …

Tumor microenvironment and mitotic checkpoint are key factors in the outcome of classic Hodgkin lymphoma

A Sánchez-Aguilera, C Montalbán, P De la Cueva… - Blood, 2006 - ashpublications.org
Around 20% to 30% of patients with Hodgkin lymphoma (HL) do not benefit from standard
therapies and finally succumb to their disease. The factors that influence the outcome of HL …

The biology of Hodgkin's lymphoma

R Küppers - Nature Reviews Cancer, 2009 - nature.com
Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however,
remained enigmatic for a long time. Only within the past 10 years has the B-cell nature of the …

The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape

D Aldinucci, A Gloghini, A Pinto… - The Journal of …, 2010 - Wiley Online Library
It has become clear that cancer is not merely a growth of autonomously proliferating cells,
but that other non‐malignant cell types are a functional part of the disease. Immune cells …

[HTML][HTML] Hodgkin lymphoma

R Küppers, A Engert… - The Journal of clinical …, 2012 - Am Soc Clin Investig
Hodgkin lymphoma (HL), a B cell–derived cancer, is one of the most common lymphomas. In
HL, the tumor cells—Hodgkin and Reed-Sternberg (HRS) cells—are usually very rare in the …

[HTML][HTML] Molecular biology of Hodgkin lymphoma

MA Weniger, R Küppers - Leukemia, 2021 - nature.com
Classical Hodgkin lymphoma (cHL) is unique among lymphoid malignancies in several key
biological features.(i) The Hodgkin and Reed-Sternberg (HRS) tumor cells are rare among …

The role of cytokines in classical Hodgkin lymphoma

BF Skinnider, TW Mak - Blood, The Journal of the American …, 2002 - ashpublications.org
The clinical and pathologic features of classical Hodgkin lymphoma (cHL) reflect an
abnormal immune response that is thought to be due to the elaboration of a variety of …